Autonomic/CV Drugs — Flashcards

Flashcard 2721: Which atypical antipsychotics are most associated with metabolic syndrome? _____

Answer: "-pines" (esp. clozapine and olanzapine)

Flashcard 2722: Which class of diabetic drugs is associated with increased risk of fracture as a possible side effect?_____

Answer: Thiazolidinediones (glitazones)

Flashcard 2723: _____ is the largest indirect thrombin inhibitor

Answer: Unfractionated heparin

Flashcard 2724: First Aid Pharmacology: Neuro/Psych Compared to thiopental, propofol has _____ post-operative nausea

Answer: less

Flashcard 2725: _____ diuretics inhibit Na+ reabsorption in the principal cells of the late DCT and collecting ducts

Answer: K+-sparing

Flashcard 2726: Stevens-Johnson syndrome in patients taking carbamazepine or phenytoin is associated with HLA-_____, which is typically seen in those of Asian ancestry

Answer: B*15:02

Flashcard 2727: Serum Sickness can be treated with pulsed _____ therapy

Answer: corticosteroid

Flashcard 2728: Opioid agonists (e.g. diphenoxylate, loperamide) treat diarrhea by activating _____ receptors in the GI tract

Answer: μ-opioid (mu)

Flashcard 2729: What is the effect of beta-blockers alone on myocardial O2 consumption?

Answer: Decreased

Extra: Beta-blockers decrease heart rate and contractility (which decreases myocardial $O_2$ consumption). \n\nNote: They can increase end-diastolic volume (EDV) and ejection time, which increases $O_2$ demand, but the overall net effect is a decrease in $MVO_2$.

Flashcard 2730: What drug class does selegiline belong to?_____

Answer: Selective MAO-B inhibitor