Autonomic/CV Drugs — Flashcards

Flashcard 2711: Stevens-Johnson syndrome in patients taking carbamazepine or phenytoin is associated with HLA-_____, which is typically seen in those of Asian ancestry

Answer: B*15:02

Flashcard 2712: Cardiovascular (Nitrates) _____ nitrate preparations have a longer duration of action than sublingual

Answer: Oral

Flashcard 2713: Which atypical antipsychotics are most associated with metabolic syndrome? _____

Answer: "-pines" (esp. clozapine and olanzapine)

Flashcard 2714: First Aid Pharmacology: Neuro/Psych Compared to thiopental, propofol has _____ post-operative nausea

Answer: less

Flashcard 2715: Serum Sickness can be treated with pulsed _____ therapy

Answer: corticosteroid

Flashcard 2716: Opioid agonists (e.g. diphenoxylate, loperamide) treat diarrhea by activating _____ receptors in the GI tract

Answer: μ-opioid (mu)

Flashcard 2717: _____ is the largest indirect thrombin inhibitor

Answer: Unfractionated heparin

Flashcard 2718: What is the effect of beta-blockers alone on myocardial O2 consumption?

Answer: Decreased

Extra: Beta-blockers decrease heart rate and contractility (which decreases myocardial $O_2$ consumption). \n\nNote: They can increase end-diastolic volume (EDV) and ejection time, which increases $O_2$ demand, but the overall net effect is a decrease in $MVO_2$.

Flashcard 2719: Bisphosphonates have a chemical structure similar to _____

Answer: pyrophosphate

Flashcard 2720: What class of drugs acts by closing K+ channels in pancreatic beta cells, causing increased insulin secretion? _____

Answer: sulfonylurea drugs (e.g. tolbutamide, glyburide)