Autonomic/CV Drugs — Flashcards

Flashcard 2671: What GAS virulence factor can be given to patients with clots? _____

Answer: Streptokinase: converts plasminogen to plasmin, which is fibrinolytic

Flashcard 2672: Dual-platelet therapy with aspirin and ADP receptor inhibitors is used to prevent coronary stent _____

Answer: thrombosis

Flashcard 2673: What is the effect of nitrates alone on heart rate?_____

Answer: Increased (reflex response)

Flashcard 2674: In addition to opioid agonist activity, dextromethorphan also antagonizes _____ receptors

Answer: NMDA

Flashcard 2675: What drug may be used to treat diabetic or post-surgical gastroparesis by increasing resting tone, contractility, and LES tone?_____

Answer: Metoclopramide (D2 receptor antagonist)

Flashcard 2676: Which calcineurin inhibitor is associated with an even greater risk for diabetes vs the other calcineurin inhibitors?_____

Answer: Tacrolimus

Flashcard 2677: Erlotinib is an _____ inhibitor is used to treat NSCLC and Pancreatic cancer

Answer: EGF-R

Flashcard 2678: One adverse effect associated with digoxin is _____ (HR)

Answer: bradycardia

Flashcard 2679: Digoxin is useful in the treatment of _____ fibrillation (and flutter)

Answer: atrial

Flashcard 2680: Is mannitol associated with hypernatremia or hyponatremia as a possible adverse effect? _____

Answer: Both

Extra: Mannitol can cause both: 1. **Hyponatremia**: Initially, mannitol expands the extracellular fluid volume by pulling water out of cells, resulting in dilutional hyponatremia. 2. **Hypernatremia**: Subsequently, it leads to osmotic diuresis. Since water is lost in excess of sodium (free water clearance), this can lead to dehydration and hypernatremia.