Autonomic/CV Drugs — Flashcards

Flashcard 2671: What 5-aminosalicylic preparations (2) are useful in the management of ulcerative colitis and Crohn disease? _____

Answer: Mesalamine and sulfasalazine

Flashcard 2672: Carbamazepine exerts its effects by blocking _____ channels

Answer: Na+

Flashcard 2673: Digoxin is useful in the treatment of _____ fibrillation (and flutter)

Answer: atrial

Flashcard 2674: Is mannitol associated with hypernatremia or hyponatremia as a possible adverse effect? _____

Answer: Both

Extra: Mannitol can cause both: 1. **Hyponatremia**: Initially, mannitol expands the extracellular fluid volume by pulling water out of cells, resulting in dilutional hyponatremia. 2. **Hypernatremia**: Subsequently, it leads to osmotic diuresis. Since water is lost in excess of sodium (free water clearance), this can lead to dehydration and hypernatremia.

Flashcard 2675: Which anti-epileptic is most associated with DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms)? _____

Answer: Phenytoin

Flashcard 2676: What high-yield sexual side effect is associated with **trazodone**?

Answer: Priapism

Extra: Trazodone is a SARI (Serotonin Antagonist and Reuptake Inhibitor) often used for insomnia. It is famously associated with priapism ('Trazo-bone') due to its α1-blocking effects. Notably, it lacks the standard sexual side effects (e.g., decreased libido, anorgasmia) associated with SSRIs.

Flashcard 2677: What is the effect of nitrates alone on heart rate?_____

Answer: Increased (reflex response)

Flashcard 2678: Sunitinib and sorafenib treat cancer due to VEGFR overexpression, such as _____ carcinoma

Answer: renal cell

Flashcard 2679: Dual-platelet therapy with aspirin and ADP receptor inhibitors is used to prevent coronary stent _____

Answer: thrombosis

Flashcard 2680: _____ is used for prophylaxis and acute management of DVT

Answer: Unfractionated or LMW heparin