Autonomic/CV Drugs — Flashcards

Flashcard 2621: PDE-5 inhibitors (e.g. sildenafil, tadalafil) are indicated for _____ hypertension

Answer: pulmonary

Flashcard 2622: Methotrexate has an _____ effect, hence why it is useful in the treatment of IBD, vasculitis, SLE, dermatomyositis, etc.

Answer: immunosuppressive

Flashcard 2623: benzodiazepines can be used in _____ (muscle relaxation, amnesia)

Answer: general anesthesia

Flashcard 2624: As part of the reversal of digoxin toxicity, _____ can be given to bind and neutralize digoxin.

Answer: Anti-digoxin Fab fragments

Flashcard 2625: First Aid Pharmacology: Neuro/Psych Vilazodone inhibits the pre-synaptic reuptake of _____

Answer: serotonin (5-HT)

Flashcard 2626: Adverse effects of clonidine include CNS and respiratory _____

Answer: depression

Flashcard 2627: What is the most serious adverse effect associated with antipsychotics? _____

Answer: Neuroleptic malignant syndrome (NMS)

Flashcard 2628: _____ is a thioamide that works by inhibiting Thyroid peroxidase ONLY

Answer: Methimazole

Flashcard 2629: Which long-acting μ-opioid receptor agonist is used to attenuate opioid withdrawal symptoms? Bonus: It is also an antagonist at which receptor?

Answer: Methadone Bonus: NMDA receptor

Flashcard 2630: What formula is used to calculate loading dose? _____

Answer: (Cp × Vd) / F

Extra: Cp = Target plasma concentration Vd = Volume of distribution F = Bioavailability Note: Loading dose depends on the **volume of distribution** (Vd). In contrast, maintenance dose depends on **clearance** (CL).