Autonomic/CV Drugs — Flashcards

Flashcard 2621: Triazolam, Oxazepam, and Midazolam are benzodiazepines that have _____ half lives

Answer: short

Flashcard 2622: First Aid Pharmacology: Neuro/Psych Vilazodone inhibits the pre-synaptic reuptake of _____

Answer: serotonin (5-HT)

Flashcard 2623: benzodiazepines can be used in _____ (muscle relaxation, amnesia)

Answer: general anesthesia

Flashcard 2624: First Aid Pharmacology: Respiratory (Asthma) _____ are the first line therapy for chronic asthma

Answer: Inhaled corticosteroids

Flashcard 2625: Thiopental causes _____ cerebral blood flow

Answer: decreased

Flashcard 2626: What formula is used to calculate loading dose? _____

Answer: (Cp × Vd) / F

Extra: Cp = Target plasma concentration Vd = Volume of distribution F = Bioavailability Note: Loading dose depends on the **volume of distribution** (Vd). In contrast, maintenance dose depends on **clearance** (CL).

Flashcard 2627: Do 1st generation H1 receptor antagonists cross the blood-brain-barrier? _____

Answer: Yes (lipophilic)

Flashcard 2628: NSAIDs can _____ blood pressure

Answer: increase

Flashcard 2629: Activation of beta-1 and beta-2 adrenergic receptors _____ lipolysis and release of fatty acids.

Answer: stimulates

Extra: Beta-receptors (β1, β2, β3) are Gs-coupled and stimulate lipolysis via the cAMP-PKA pathway, which activates hormone-sensitive lipase. Conversely, α2 receptors are Gi-coupled and inhibit lipolysis.

Flashcard 2630: What drug class is the most common cause of drug overdose death? _____

Answer: Opioids (e.g. heroin)