Autonomic/CV Drugs — Flashcards

Flashcard 2621: Does administering HCO3 for tricyclic antidepressant toxicity accelerate drug metabolism?_____

Answer: No - only overcomes Na channel-blocking activity

Flashcard 2622: First Aid Pharmacology: Neuro/Psych Vilazodone inhibits the pre-synaptic reuptake of _____

Answer: serotonin (5-HT)

Flashcard 2623: What type of diabetes may be induced by glucocorticoid use? _____

Answer: Steroid diabetes

Flashcard 2624: Capsaicin causes release and subsequent depletion of _____

Answer: substance P

Flashcard 2625: What drug class is the most common cause of drug overdose death? _____

Answer: Opioids (e.g. heroin)

Flashcard 2626: Which local anesthetic is commonly associated with cardiac arrhythmias?

Answer: Cocaine

Flashcard 2627: Activation of beta-1 and beta-2 adrenergic receptors _____ lipolysis and release of fatty acids.

Answer: stimulates

Extra: Beta-receptors (β1, β2, β3) are Gs-coupled and stimulate lipolysis via the cAMP-PKA pathway, which activates hormone-sensitive lipase. Conversely, α2 receptors are Gi-coupled and inhibit lipolysis.

Flashcard 2628: Do 1st generation H1 receptor antagonists cross the blood-brain-barrier? _____

Answer: Yes (lipophilic)

Flashcard 2629: Which osmotic diuretic may cause dehydration as a possible adverse effect? _____

Answer: Mannitol

Flashcard 2630: What effect do thrombolytics have on platelet count?_____

Answer: No effect