Autonomic/CV Drugs — Flashcards

Flashcard 2611: Evolocumab binds PCSK9 and _____ degradation of hepatic LDL receptors

Answer: prevents

Flashcard 2612: One adverse effect associated with digoxin is _____ due to parasympathetic activity at AV node

Answer: heart block

Flashcard 2613: Activation of beta-1 and beta-2 adrenergic receptors _____ lipolysis and release of fatty acids.

Answer: stimulates

Extra: Beta-receptors (β1, β2, β3) are Gs-coupled and stimulate lipolysis via the cAMP-PKA pathway, which activates hormone-sensitive lipase. Conversely, α2 receptors are Gi-coupled and inhibit lipolysis.

Flashcard 2614: What type of diabetes may be induced by glucocorticoid use? _____

Answer: Steroid diabetes

Flashcard 2615: Do 1st generation H1 receptor antagonists cross the blood-brain-barrier? _____

Answer: Yes (lipophilic)

Flashcard 2616: First Aid Pharmacology: Endocrine_____ is a possible teratogenic complication of methimazole if given in the first trimester

Answer: Aplasia cutis

Flashcard 2617: NSAIDs can _____ blood pressure

Answer: increase

Flashcard 2618: Does administering HCO3 for tricyclic antidepressant toxicity accelerate drug metabolism?_____

Answer: No - only overcomes Na channel-blocking activity

Flashcard 2619: How can prolactin excess be treated? _____

Answer: dopamine agonists (e.g. bromocriptine)

Flashcard 2620: Wet macular degeneration is treated with smoking cessation (if applicable) and _____ injections

Answer: anti-VEGF