Autonomic/CV Drugs — Flashcards

Flashcard 2481: Linagliptin, saxagliptin, and sitagliptin are all examples of _____

Answer: DPP-4 inhibitors

Flashcard 2482: Which IV anesthetic preserves cardiovascular stability? _____

Answer: Etomidate

Flashcard 2483: What is the effect of glucocorticoids on production of phospholipase A2?_____

Answer: Decreased (inhibition)

Flashcard 2484: Statins indirectly cause _____ LDL receptor expression on hepatocytes

Answer: increased

Flashcard 2485: Exenatide and liraglutide are both examples of _____

Answer: GLP-1 agonists

Flashcard 2486: What effect does dobutamine have on HR and contractility? _____

Answer: Increased HR and contractility (β₁ agonist)

Flashcard 2487: Which class of diabetic drugs is associated with increased risk of heart failure as a possible side effect?_____

Answer: Thiazolidinediones

Flashcard 2488: What adverse effect is characteristically associated with **streptokinase** (due to its bacterial origin)?

Answer: Hypersensitivity / allergic reactions (including anaphylaxis)

Extra: Streptokinase is a protein produced by beta-hemolytic streptococci. Because it is a foreign bacterial protein, it is antigenic and can induce antibody production. This leads to two main issues: 1. **Hypersensitivity reactions:** Range from simple rashes/fever to life-threatening anaphylaxis. 2. **Neutralization:** Pre-existing antibodies (from prior streptococcal infections or previous streptokinase use) can neutralize the drug, making it less effective. Recombinant human tPA (e.g., alteplase) does not carry this risk of antigenicity.

Flashcard 2489: Etanercept works by complexing with TNF-a and inducing _____ of the complex

Answer: phagocytosis

Flashcard 2490: What drug class do alteplase, reteplase, tenecteplase belong to? _____

Answer: Thrombolytics (recombinant tPA)