Autonomic/CV Drugs — Flashcards

Flashcard 2351: Alpha-glucosidase inhibitors (e.g. acarbose, miglitol) reduce the activity of alpha-glucosidases on the _____, thus delaying carbohydrate hydrolysis and absorption

Answer: intestinal brush border

Flashcard 2352: Cardiac glycosides (e.g. digoxin) exert their effects via inhibition of the _____ pump

Answer: Na+-K+ ATPase

Flashcard 2353: NSAIDs increase the risk of GI bleeding primarily through the inhibition of which enzyme?

Answer: COX-1

Extra: Inhibition of **COX-1** leads to: 1. Decreased **PGE2 and PGI2**: Reduces gastric mucosal protection (decreases mucus and bicarbonate secretion, decreases blood flow). 2. Decreased **TXA2**: Inhibits platelet aggregation, which increases the tendency to bleed from any mucosal damage.

Flashcard 2354: Which thyroid medications are associated with drug-induced lupus?_____

Answer: Propylthiouracil (PTU), methimazole

Flashcard 2355: What effect do class IB antiarrhythmics have on action potential duration? _____

Answer: Shortened duration

Flashcard 2356: Which anti-epileptic may be used to treat peripheral neuropathy and fibromyalgia (chronic pain)? _____

Answer: Pregabalin

Flashcard 2357: Irinotecan and topotecan can result in _____-suppression

Answer: myelo

Flashcard 2358: What major GI side effect is associated with verapamil? _____

Answer: Constipation

Flashcard 2359: What are 2nd generation H1 receptor antagonists used to treat? _____

Answer: Allergies

Flashcard 2360: Epinephrine causes _____ mean arterial pressure

Answer: increased