Autonomic/CV Drugs — Flashcards

Flashcard 211: Sacubitril is a(n) _____ inhibitor

Answer: neprilysin

Extra: #REF!Watch associated Bootcamp video [https://app.bootcamp.com/med-school/cardiology/videos/heart-failure?index=6] https://onlinemeded.org/spa/cardiology/heart-failure/acquire?ref=anki 

Flashcard 212: Can cortisone activate mineralocorticoid receptors? _____

Answer: No

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/nephrology/videos/nephron-transporters?index=8] https://onlinemeded.org/spa/renal?ref=anki 

Flashcard 213: Treatment for central diabetes insipidus includes hydration and _____, which is an ADH analog

Answer: desmopressin

Extra:   Watch Diabetes Insipidus & SIADH [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-endocrine/videos/medical-pathophysiology-endocrine-hypothalamic-and-pituitary-disorders-diabetes-insipidus-and-siadh?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/nephrology/videos/electrolytes?index=2] https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki 

Flashcard 214: Use of Linezolid is contraindicated in patients taking drugs that increase _____ transmission

Answer: serotonergic

Flashcard 215: Chronic levodopa use can cause an "_____ phenomenon", with periods of akinesia alternating with periods of improved mobility

Answer: on-off

Extra:   Sketchy Pharmacology: Neuro/Psych Watch Levodopa/carbidopa, entacapone, tolcapone, selegiline, ropinirole, pramipexole, amantadine [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-neuro-psych/videos/medical-pharmacology-neuropsych-antipsychotics-and-parkinsons-levodopacarbidopa-entacapone-tolcapone-selegiline-ropinirole-pramipexole-amantadine?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/neurology/videos/dementia?index=3] https://onlinemeded.org?ref=anki 

Flashcard 216: The treatment for barbiturate overdose is mainly _____ treatment, but excretion can be enhanced with urinary alkalinization

Answer: supportive

Extra:  First Aid Pharmacology: Neuro/Psych  Watch Barbiturates [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-neuro-psych/videos/medical-pharmacology-neuropsych-sedative-hypnotics-barbiturates?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org?ref=anki 

Flashcard 217: _____ and Sulfa drugs are both known to cause drug-induced lupus (syndrome associated with anti-histone antibodies).

Answer: Etanercept

Extra: Drug-induced lupus is characterized by anti-histone antibodies and the absence of anti-dsDNA antibodies. Etanercept is a TNF-α inhibitor. Watch associated Bootcamp video: https://app.bootcamp.com/med-school/immunology/videos/transplant-rejection?index=16

Flashcard 218: Fondaparinux is an anticoagulant that acts only on factor _____

Answer: Xa

Extra:   Watch Heparin, LMWH, fondaparinux, direct thrombin inhibitors, Xa inhibitors [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-blood-inflammation/videos/medical-pharmacology-blood-and-inflammation-anticoagulants-and-thrombolytics-heparin-lmwh-fondaparinux-direct-thrombin-inhibitors-xa-inhibitors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/coagulation-and-fibrinolysis?index=11] https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki 

Flashcard 219: Which of the vinca alkaloids is more commonly associated with paralytic ileus? _____

Answer: Vincristine

Extra:  Watch Vincristine, vinblastine, paclitaxel [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antineoplastics/videos/medical-pharmacology-antineoplastics-dna-and-cellular-division-vincristine-vinblastine-paclitaxel?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/mitosis-meiosis-and-the-cell-cycle?index=2] https://onlinemeded.org?ref=anki 

Flashcard 220: Coadministration of ACE inhibitors with _____ can precipitate acute kidney injury

Answer: NSAIDs

Extra:  FA2020 UPDATE: ACE inhibitors dilate the efferent arteriole, not constrict as the image below states:  Sketchy Pharmacology: Cardiovascular/Renal Watch ACE inhibitors, ARBs, Aliskiren [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-cardiovascular-renal/videos/medical-pharmacology-cardiovascular-and-renal-heart-failure-drugs-ace-inhibitors-arbs-aliskiren?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/cardiology/hypertension/acquire?ref=anki  NSAIDs decrease afferent dilation by prostaglandins, ACE Inhibitors vasodilate efferent arteriole (overall less blood flow to kidney)