Autonomic/CV Drugs — Flashcards

Flashcard 2141: Which kinase inhibitor can be used to treat non-small cell lung cancer (NSCLC) with EGFR mutations?

Answer: Erlotinib

Flashcard 2142: Sunitinib and sorafenib are associated with an increased risk of _____

Answer: hemorrhage and hyperkeratosis (hand-foot skin reaction)

Extra: Sunitinib and sorafenib are multi-kinase inhibitors (targeting VEGFR, PDGFR, and c-KIT). High-yield side effects include hypertension, hemorrhage, and hyperkeratotic skin reactions (hand-foot syndrome). Note: Sunitinib is also associated with a yellow skin discoloration and hair depigmentation.

Flashcard 2143: Ursodiol primarily works in Primary Biliary Cholangitis by protecting hepatocytes against _____

Answer: apoptosis

Flashcard 2144: Allopurinol can result in _____-philia

Answer: eosino

Flashcard 2145: What calcium channel blocker may be combined with nitrates, producing similar effects to β-blockers?

Answer: Verapamil

Flashcard 2146: Is the heart failure associated with Trastuzumab reversible with treatment discontinuation?_____

Answer: Yes

Flashcard 2147: Class I antiarrhythmics exert their actions by blocking _____ channels

Answer: Na+

Flashcard 2148: What drug class do gemfibrozil and fenofibrate belong to? _____

Answer: Fibrates

Flashcard 2149: β1 selective antagonists primarily suppress adrenergic stimulation of the _____

Answer: heart (cardioselective)

Flashcard 2150: Dronabinol (medical marijuana) is used clinically as an _____ for AIDS patients

Answer: appetite stimulant