Autonomic/CV Drugs — Flashcards

Flashcard 2051: The inhaled anesthetic _____ is associated with expansion of trapped gas in a body cavity as an adverse effect

Answer: N2O

Flashcard 2052: One factor that predisposes to digoxin toxicity is _____, which increases binding of digoxin to Na+-K+ ATPase

Answer: hypokalemia

Flashcard 2053: Which antacid is associated with hypophosphatemia and osteodystrophy if overused? _____

Answer: Aluminum hydroxide

Flashcard 2054: Autonomics ( blockers) _____ -blockers are useful in the management of chronic heart failure

Answer: Cardioselective

Flashcard 2055: **Methotrexate** must be monitored with LFTs because chronic use increases the risk of hepatic fibrosis and _____.

Answer: cirrhosis (hepatic fibrosis)

Extra: Methotrexate is a folate antagonist (inhibits dihydrofolate reductase) used for rheumatoid arthritis, psoriasis, and certain malignancies. Chronic use is associated with hepatotoxicity, specifically the development of hepatic fibrosis and cirrhosis, which necessitates periodic monitoring of liver function tests (LFTs). It is also associated with myelosuppression and pulmonary fibrosis.

Flashcard 2056: Cardiovascular (Antiarrhythmics) _____ is a purine nucleoside with antiarrhythmic properties

Answer: Adenosine

Flashcard 2057: Methadone and buprenorphine are useful for opioid detoxication due to their _____ half lives

Answer: long

Flashcard 2058: What T3 hormone analog is used to treat hypothyroidism and myxedema?

Answer: Liothyronine

Extra: Levothyroxine is the T4 analog (drug of choice for hypothyroidism). Liothyronine is the T3 analog (faster onset, used in myxedema coma).

Flashcard 2059: What is a serious complication of vaptans (e.g. tolvaptan, conivaptan) that may occur if SIADH-induced hyponatremia is corrected too quickly? _____

Answer: Central pontine myelinolysis (osmotic demyelination syndrome)

Flashcard 2060: Adverse effects of suvorexant include CNS depression, headache, dizziness, abnormal dreams, and _____ infection

Answer: upper respiratory tract