Autonomic/CV Drugs — Flashcards

Flashcard 1601: Is protamine sulfate effective at reversing the effects of LMWH and fondaparinux? _____

Answer: LMWH: Partially reversed; Fondaparinux: Not reversed

Extra: Protamine sulfate is the specific antagonist for Unfractionated Heparin (UFH). It only partially reverses LMWH (approximately 60-75%) and has no effect on Fondaparinux.

Flashcard 1602: What is the mechanism of action of warfarin?_____

Answer: Epoxide reductase inhibitor

Flashcard 1603: Why is there a relative protein C and S deficiency in the initial stages of warfarin therapy?

Answer: Protein C and S have shorter half-lives than factors II, IX, and X

Flashcard 1604: Valproic acid _____ levels of GABA in the CNS via inhibition of GABA transaminase

Answer: increases

Flashcard 1605: _____ is an immunosuppressant that can be used in drug-eluting stents

Answer: Sirolimus (rapamycin)

Flashcard 1606: Adverse effects associated with phenytoin include diplopia and _____ (eye complications)

Answer: nystagmus

Flashcard 1607: Is aspirin a reversible or irreversible inhibitor of COX-1 and COX-2?_____

Answer: Irreversible

Flashcard 1608: What is the predominant autonomic receptor on the pupillary sphincter muscle? _____

Answer: M3

Flashcard 1609: Eltrombopag is a _____ receptor agonist used to treat thrombocytopenia

Answer: Thrombopoietin (TPO)

Flashcard 1610: Ouabain is a cardiac glycoside that inhibits the _____ pump by binding to the K+ site

Answer: Na+-K+ ATPase