Autonomic/CV Drugs — Flashcards

Flashcard 1581: Do mineralocorticoid receptor antagonists (e.g. spironolactone, eplerenone) prolong life in heart failure?_____

Answer: Yes

Flashcard 1582: _____-acting benzodiazepines are typically metabolized by the liver into active metabolites.

Answer: Long

Flashcard 1583: What MSK pathology is associated with heparin use? _____

Answer: Osteoporosis

Flashcard 1584: Initially, immune thrombocytopenia (ITP) can be treated with steroids. If it becomes refractory, the patient can be given _____mab. **Bonus:** What drug used in ITP inhibits splenic macrophages?

Answer: Rituximab **Bonus:** IVIG (Intravenous Immunoglobulin)

Extra: Rituximab is a monoclonal antibody against CD20 found on B-cells. IVIG (Intravenous Immunoglobulin) works in ITP by blocking the Fc receptors on splenic macrophages, preventing them from phagocytosing and destroying antibody-coated platelets.

Flashcard 1585: Lithium is almost exclusively excreted by the _____

Answer: kidneys

Flashcard 1586: Colchicine is primarily used for treatment of diseases that involve dysfunction of _____

Answer: neutrophils

Flashcard 1587: Eculizumab is indicated for the treatment of _____

Answer: Paroxysmal Nocturnal Hemoglobinuria

Flashcard 1588: Treatment of iron deficiency anemia involves supplemental _____

Answer: iron (ferrous sulfate)

Flashcard 1589: Which class of anti-platelet drugs may cause TTP as an adverse effect?_____

Answer: ADP receptor inhibitors

Flashcard 1590: What dermatologic complication is associated with phenytoin use? _____

Answer: Stevens-Johnson syndrome