Autonomic/CV Drugs — Flashcards

Flashcard 1531: Barbiturates can cause severe CNS depression (e.g. coma) and should be avoided in _____ patients

Answer: elderly

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 1532: What drug intoxication presents as euphoria, slow reflexes, increased appetite, paranoia, and dry mouth? _____

Answer: Marijuana

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 1533: β-blockers = _____cardia

Answer: brady

Extra:  https://onlinemeded.org/spa/cardiology?ref=anki 

Flashcard 1534: What is the mechanism of OCP that reduces the risk of endometrial cancer? _____

Answer: Progestin counteracts estrogen's effect on endometrial proliferation

Extra:  https://onlinemeded.org/spa/gynecology/endometrial-cancer/acquire?ref=anki 

Flashcard 1535: Carbamazepine exerts its effects by blocking _____ channels

Answer: Na+

Extra:  Sketchy Pharmacology: Neuro/Psych  https://onlinemeded.org?ref=anki 

Flashcard 1536: Which selective estrogen receptor modulator (SERM) is preferred for treatment of postmenopausal osteoporosis? _____

Answer: Raloxifene

Extra: Raloxifene is an estrogen agonist in bone (prevents resorption) but an antagonist in breast and endometrial tissue. Unlike tamoxifen, it does not increase the risk of endometrial cancer.

Flashcard 1537: All ER+ and/or PR+ breast cancers should receive _____ or aromatase inhibitors

Answer: tamoxifen

Flashcard 1538: NSAIDs should not be used for treatment of gout in patients taking _____ (e.g. aspirin, apixaban) or who have renal insufficiency

Answer: anticoagulants or antiplatelets

Extra: https://onlinemeded.org/spa/rheumatology/monoarticuloarthropathy/acquire?ref=anki

Flashcard 1539: Dihydropyridine CCBs may be used to treat _____, which is an exaggerated vascular response to cold temperature or emotional stress

Answer: Raynaud's phenomenon

Extra:  https://onlinemeded.org/spa/rheumatology/other-connective-tissue/acquire?ref=anki 

Flashcard 1540: Match the signaling components with their associated hormones or drugs: - cGMP-dependent protein kinase (PKG) - Janus tyrosine kinase (JAK) - Phosphodiesterase (PDE) - Protein kinase A (PKA) - Tyrosine-specific receptor kinase (RTK)

Answer: 1. PKG: NO, Nitrates, Sildenafil (via cGMP). 2. JAK: GH, Cytokines (PIGGLET). 3. PDE: Degrades cAMP/cGMP. Inhibited by Sildenafil, Theophylline. 4. PKA: FLAT ChAMP (FSH, LH, ACTH, TSH, CRH, hCG, ADH-V2, MSH, PTH) and Glucagon. 5. RTK: Insulin, IGF-1, FGF, PDGF, EGF.