Antimicrobials — Flashcards

Flashcard 761: Which phase of the cell cycle does topotecan act at?

Answer: S phase

Extra: Topotecan and Irinotecan are **Topoisomerase I inhibitors**, which are cell cycle-specific for the **S phase**. In contrast, Topoisomerase II inhibitors (e.g., Etoposide, Teniposide) act in the **S and G2 phases**.

Flashcard 762: Colchicine can affect the muscle, resulting in a _____

Answer: myopathy

Flashcard 763: Treatment of acne vulgaris may include vitamin _____ derivatives, which reduces hyperkeratinzation and sebum production

Answer: A

Flashcard 764: Chloroquine and hydroxychloroquine are antimalarials that can be used to cause _____-suppression as well as retinopathy

Answer: immuno

Flashcard 765: Prior to a bone marrow transplant, Busulfan can be used as a _____ agent

Answer: conditioning

Flashcard 766: Methotrexate is a _____ analog

Answer: folate

Flashcard 767: What type of vaccine is used for Yersinia pestis?_____

Answer: Inactivated/Killed

Flashcard 768: What class of drugs does lomustine belong to?_____

Answer: Nitrosoureas (alkylating agent)

Flashcard 769: What class of drugs does streptozocin belong to?_____

Answer: Nitrosoureas (alkylating agent)

Flashcard 770: Trimethoprim-Sulfamethoxazole (TMP-SMX) are used for prophylaxis and treatment of _____ pneumonia

Answer: Pneumocystis jirovecii