Antimicrobials — Flashcards

Flashcard 751: Cytarabine can result in _____-suppression (-cytopenias)

Answer: myelo

Flashcard 752: Onchocerca volvulus is treated with _____

Answer: ivermectin

Flashcard 753: What drug inhibits dihydrofolate reductase in protozoa?_____

Answer: Pyrimethamine (not bacteria)

Flashcard 754: What treatments (2) are used to boost granulocyte production and thus decrease risk of infection in neutropenic patients? _____

Answer: GM-CSF or G-CSF

Flashcard 755: Which phase of the cell cycle does topotecan act at?

Answer: S phase

Extra: Topotecan and Irinotecan are **Topoisomerase I inhibitors**, which are cell cycle-specific for the **S phase**. In contrast, Topoisomerase II inhibitors (e.g., Etoposide, Teniposide) act in the **S and G2 phases**.

Flashcard 756: What type of vaccine is used for Yersinia pestis?_____

Answer: Inactivated/Killed

Flashcard 757: Which chemotherapeutic drug can be used to raise fetal hemoglobin (HbF) levels?_____

Answer: Hydroxyurea

Flashcard 758: Methotrexate can result in pulmonary fibrosis and ultimately _____ disease

Answer: restrictive lung

Flashcard 759: What treatment for hyperammonemia acts by acidifying the GI tract, thus trapping NH4+ for excretion? _____

Answer: Lactulose

Flashcard 760: What type of vaccine is used for Bordetella pertussis in infants and children?_____

Answer: Acellular (DTaP)