Antimicrobials — Flashcards

Flashcard 601: What is the formula for calculating drug clearance (CL)?

Answer: CL = Rate of elimination / Plasma drug concentration

Extra: CL = Vd × Ke = (0.693 × Vd) / t1/2

Flashcard 602: Which types of vaccine induce a relatively weak immune response? _____

Answer: Inactivated/killed vaccines and Subunit vaccine (2)

Flashcard 603: What is the effect of glucocorticoids on blood lymphocyte levels? _____

Answer: Decreased (especially T-helper cells)

Flashcard 604: Which chemotherapeutic drug is known to cause acute tubular necrosis?_____

Answer: Cisplatin

Flashcard 605: Which antimalarial can result in retinopathy?_____

Answer: Chloroquine

Flashcard 606: Which topoisomerase I inhibitor is indicated in ovarian and small cell lung cancer?_____

Answer: topotecan

Flashcard 607: What osmotic laxative is used to treat hepatic encephalopathy? _____

Answer: Lactulose

Flashcard 608: What is the treatment of late (CNS) Trypanosoma brucei infection?_____

Answer: Melarsoprol

Flashcard 609: In the treatment of Multiple Sclerosis, Natalizumab works by preventing extravasation of autoreactive _____ T Cells

Answer: CD4+

Flashcard 610: Etoposide and teniposide inhibit the _____ of double stranded breaks caused by topoisomerase II

Answer: religation