Antimicrobials — Flashcards

Flashcard 581: Cyclophosphamide requires bioactivation by _____ enzymes to be effective

Answer: Cytochrome P450

Flashcard 582: Mycophenolate mofetil can result in _____-suppression (-cytopenias)

Answer: myelo

Flashcard 583: Which phase of the cell cycle does azathioprine act at?_____

Answer: S phase

Flashcard 584: Gemcitabine can result in _____ with increased risk for infection

Answer: immunosuppression

Flashcard 585: Cetuximab is an antitumor monoclonal antibody that targets _____

Answer: EGFR

Flashcard 586: What is the effect of glucocorticoids on blood lymphocyte levels? _____

Answer: Decreased (especially T-helper cells)

Flashcard 587: What is the formula for calculating drug clearance (CL)?

Answer: CL = Rate of elimination / Plasma drug concentration

Extra: CL = Vd × Ke = (0.693 × Vd) / t1/2

Flashcard 588: Which form of immune hemolytic anemia (IgG or IgM) may be caused by drugs? _____

Answer: IgG

Flashcard 589: Which antimalarial can result in retinopathy?_____

Answer: Chloroquine

Flashcard 590: Which topoisomerase I inhibitor is indicated in ovarian and small cell lung cancer?_____

Answer: topotecan