Antimicrobials — Flashcards

Flashcard 261: The suffix _____ is associated with the Carbapenem class of antimicrobials

Answer: -penem

Flashcard 262: Which of the topoisomerase inhibitors are associated with severe diarrhea? _____

Answer: irinotecan, topotecan

Flashcard 263: Which of the vinca alkaloids is more commonly associated with areflexia and peripheral neuritis? _____

Answer: Vincristine

Flashcard 264: Which alkylating agent is used to treat both hematologic malignancies (leukemia, lymphoma) and solid tumors? _____

Answer: Cyclophosphamide

Flashcard 265: _____ inhibits the enzyme acetaldehyde dehydrogenase

Answer: Disulfiram

Extra: Disulfiram inhibits aldehyde dehydrogenase and is used as an aversive agent that discourages drinking by causing an unpleasant physiologic reaction when alcohol is consumed.  Candidates for disulfiram must be abstinent and highly motivated.

Flashcard 266: Drugs that act on microtubules may be remembered with the mnemonic "Microtubules Get Constructed Very Poorly": M: _____ G: Griseofulvin (antifungal) C: Colchicine (antigout) V: Vincristine/Vinblastine (anticancer) P: Paclitaxel (anticancer)

Answer: Mebendazole (antihelminthic)

Flashcard 267: Erlotinib therapy is associated with _____ and diarrhea (adverse effects)

Answer: acneiform skin rash

Flashcard 268: Strongyloides stercoralis is treated with _____ or ivermectin

Answer: albendazole

Flashcard 269: Which chemotherapeutic drug is first-line in the treatment of rheumatoid arthritis? _____

Answer: Methotrexate

Flashcard 270: Alkylating agents donate a(n) _____ group that _____ DNA, resulting in cell apoptosis

Answer: alkyl