Antimicrobials — Flashcards

Flashcard 231: Which chemotherapeutic drug is known to result in muddy brown casts found in urine? _____

Answer: Cisplatin

Flashcard 232: Which of the platinum analogs is most commonly associated with nephrotoxicity? _____

Answer: Cisplatin

Flashcard 233: PEGylated Liposomal Doxorubicin is useful for the treatment of _____

Answer: Kaposi Sarcoma

Flashcard 234: Sulfonamides increase the risk of _____ when taken along with Warfarin

Answer: bleeding

Flashcard 235: What enzyme is blocked by the immunosuppressant mycophenolate mofetil? _____

Answer: IMP dehydrogenase

Flashcard 236: Which anti-epileptic is most associated with DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms)? _____

Answer: Phenytoin

Extra: Sketchy Pharmacology: Neuro/Psych

Flashcard 237: Cladribine can result in _____ with increased risk for infection

Answer: immunosuppression

Flashcard 238: Antimetabolites (Methotrexate, 5FU, Hydroxyurea) blocks the progression of _____ phase

Answer: S

Flashcard 239: Anions such as _____, pertechnetate, and thiocyanate competively inhibit the sodium-iodide transporter

Answer: perchlorate

Flashcard 240: Platinum analogs are associated with _____ and _____

Answer: nephrotoxicity

Extra: Platinum analogs include cisplatin, carboplatin, and oxaliplatin. Note: Amifostine can be used to prevent cisplatin-induced nephrotoxicity.