Neoplasia — Flashcards

Flashcard 651: Clonality can be determined via _____ isoforms in females

Answer: G6PD

Flashcard 652: _____ gastric ulcers are usually large and irregular with heaped up margins

Answer: Malignant

Extra: Gastric cancer Endoscopy of the gastric antrum: gastric cancer of the lesser curvature with an irregular margin (perimeter marked by green outline) and central ulceration (green overlay). Atlas:

Flashcard 653: Which breast cancer is characterized histologically by nests of purple glandular tissue surrounded by dense pink fibrous stroma? _____

Answer: Invasive ductal carcinoma

Extra: * due to desmoplastic reaction; may be described as hypercellular ducts with irregular dark purple cells

Flashcard 654: Which rosettes are seen in Neuroblastoma? _____

Answer: Homer-Wright Rosettes

Extra: Atlas: Other:

Flashcard 655: _____ tumors usually display uniform nuclei

Answer: Benign

Flashcard 656: What is the mechanism that results in malignancy from the CDK4 oncogene? _____

Answer: amplification

Flashcard 657: On electron microscopy, carcinoid tumor cells display dense cytoplasmic _____ (contain secretory products and hormones)

Answer: granules

Flashcard 658: Mutations in c-Myc can cause Burkitt Lymphoma via a t(_____) translocation to the Ig Heavy Chain locus

Answer: 8;14

Flashcard 659: Most notably, the serum tumor marker _____ is elevated in testicular germ cell tumors and ovarian dysgerminoma

Answer: LDH

Flashcard 660: Which has more prognostic value, tumor stage or grade? _____

Answer: Tumor Stage