Paraneoplastic syndromes — Flashcards

Flashcard 1: Marantic Endocarditis and Trousseau Syndrome can present as paraneoplastic syndromes associated with visceral _____

Answer: Adenocarcinomas

Flashcard 2: A common cause of Addison disease is metastatic carcinoma, especially from the _____

Answer: lungs

Flashcard 3: Which renal neoplasia is associated with paraneoplastic syndromes? _____

Answer: Renal cell carcinoma

Flashcard 4: The _____ is a unique site of distant metastasis from lung cancer

Answer: adrenal gland

Flashcard 5: Renal cell carcinoma may present with paraneoplastic syndromes, such as secondary _____ (hematocrit levels)

Answer: polycythemia

Flashcard 6: Hypertrophic Osteoarthropathy is caused by an abnormal _____ of skin and bone at distal extremities

Answer: proliferation

Flashcard 7: Ovarian tumor associated with a pulling sensation in the groin and histology showing bundles of spindle-shaped fibroblasts?

Answer: Ovarian Fibroma

Extra: • Clinical: Pulling sensation in groin. • Histology: Bundles of spindle-shaped fibroblasts. • Association: Meigs syndrome (Ovarian fibroma, Ascites, Hydrothorax).

Flashcard 8: What is the characteristic histological finding and cell type in a Brenner tumor?

Answer: "Coffee bean" nuclei; contains Walthard cell rests (transitional epithelium)

Extra: Brenner tumor: - Mostly benign ovarian surface epithelial tumor. - Histology: Characterized by "coffee bean" nuclei (longitudinal nuclear grooves) and nests of transitional epithelium (resembling bladder mucosa) called Walthard cell rests. - Gross: Solid, tan-white/yellow, well-encapsulated.

Flashcard 9: Is mucinous cystadenocarcinoma benign or malignant?

Answer: Malignant

Extra: Mucinous cystadenocarcinoma is the malignant counterpart of mucinous cystadenoma. It is a common primary surface epithelial tumor of the ovary, characterized by multiloculated cysts lined by atypically proliferated mucinous epithelium showing stromal invasion.

Flashcard 10: Morphological features of Mucinous Cystadenoma?

Answer: Multilocular cyst lined by mucus-secreting epithelium (Benign)

Extra: Mucinous cystadenomas are most commonly found in the ovary or pancreas. Characterized by large, multiloculated cysts filled with gelatinous fluid. Unlike serous cystadenomas, these are less likely to be bilateral in the ovary.