Carcinogenic agents — Flashcards

Flashcard 1: Which carcinogen is associated with the following types of cancer? - Squamous cell carcinoma (oropharynx and upper esophagus) - Pancreatic carcinoma - Hepatocellular carcinoma

Answer: Ethanol

Flashcard 2: Which carcinogen is associated with both bronchogenic carcinoma and mesothelioma?

Answer: Asbestos

Flashcard 3: Which form of radiation is associated with the following types of cancer? - AML - CML - Papillary thyroid carcinoma

Answer: Ionizing radiation

Flashcard 4: Aflatoxins are carcinogenic, especially for the development of _____ carcinoma

Answer: hepatocellular

Flashcard 5: Which form of radiation is associated with the following types of cancer?_____ Basal Cell Carcinoma of the SkinSquamous Cell Carcinoma of the SkinMelanoma of the Skin

Answer: Non-Ionizing Radiation

Flashcard 6: Which oncogenic microbes are associated with the following cancers?:_____Hepatocellular Carcinoma

Answer: HBV, HCV, Aspergillus (3)

Flashcard 7: Which oncogenic microbe is associated with the following cancers?:_____Adult T-cell Leukemia / Lymphoma

Answer: HTLV-1

Flashcard 8: Ovarian tumor associated with a pulling sensation in the groin and histology showing bundles of spindle-shaped fibroblasts?

Answer: Ovarian Fibroma

Extra: • Clinical: Pulling sensation in groin. • Histology: Bundles of spindle-shaped fibroblasts. • Association: Meigs syndrome (Ovarian fibroma, Ascites, Hydrothorax).

Flashcard 9: What is the characteristic histological finding and cell type in a Brenner tumor?

Answer: "Coffee bean" nuclei; contains Walthard cell rests (transitional epithelium)

Extra: Brenner tumor: - Mostly benign ovarian surface epithelial tumor. - Histology: Characterized by "coffee bean" nuclei (longitudinal nuclear grooves) and nests of transitional epithelium (resembling bladder mucosa) called Walthard cell rests. - Gross: Solid, tan-white/yellow, well-encapsulated.

Flashcard 10: Is mucinous cystadenocarcinoma benign or malignant?

Answer: Malignant

Extra: Mucinous cystadenocarcinoma is the malignant counterpart of mucinous cystadenoma. It is a common primary surface epithelial tumor of the ovary, characterized by multiloculated cysts lined by atypically proliferated mucinous epithelium showing stromal invasion.