Tumor suppressor genes — Flashcards

Mutations in which tumor suppressor gene can lead to von Hippel-Lindau disease?_____

Mutations in which tumor suppressor genes can lead to Wilms Tumors?_____

Li-Fraumeni syndrome is characterized by multiple malignancies at an _____ age

Mutations in which tumor suppressor gene can lead to Melanoma, Pancreatic Cancer, and Dysplastic Nevus Syndrome?_____

Loss of p53 is seen in >_____% of cancers

Which tumor suppressor gene is associated with von Hippel-Lindau disease?_____

What inherited cancers (2) are associated with osteosarcoma? _____

Which tumor suppressor gene is associated with melanoma and pancreatic cancer?_____

A _____ of function mutation to a tumor suppressor gene increases the risk of cancer

Which tumor suppressor genes are associated with Wilms tumor (nephroblastoma)?_____