DNA repair genes and cancer — Flashcards

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DNA repair genes and cancer — Flashcards

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Read Study Notes Questions

What pathology is characterized by a deficiency of the enzymes used in mismatch base repair? _____

Lynch syndrome and some sporadic colorectal carcinomas arise via the _____ instability pathway

Homologous Recombination is defective in breast/ovarian cancers with _____ mutations

Which tumor suppressor genes are associated with breast, ovarian, fallopian and pancreatic cancer?_____

Which autosomal dominant syndrome is associated with increased risk for colon, ovarian, and endometrial carcinoma? _____

What type of gene is the APC gene? _____

Ovarian tumor associated with a pulling sensation in the groin and histology showing bundles of spindle-shaped fibroblasts?

What is the characteristic histological finding and cell type in a Brenner tumor?

Is mucinous cystadenocarcinoma benign or malignant?

#10

Morphological features of Mucinous Cystadenoma?

DNA repair genes and cancer US Medical PG Flashcards - Medical Study Cards

Master DNA repair genes and cancer with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.

DNA repair genes and cancer Flashcard Deck - 10 Cards

Flashcard 1: What pathology is characterized by a deficiency of the enzymes used in mismatch base repair? _____

Answer: Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC])

Flashcard 2: Lynch syndrome and some sporadic colorectal carcinomas arise via the _____ instability pathway

Answer: microsatellite

Flashcard 3: Homologous Recombination is defective in breast/ovarian cancers with _____ mutations

Answer: BRCA1/2

Flashcard 4: Which tumor suppressor genes are associated with breast, ovarian, fallopian and pancreatic cancer?_____

Answer: BRCA1/BRCA2

Flashcard 5: Which autosomal dominant syndrome is associated with increased risk for colon, ovarian, and endometrial carcinoma? _____

Answer: Lynch syndrome (HNPCC)

Flashcard 6: What type of gene is the APC gene? _____

Answer: Tumor suppressor gene

Flashcard 7: Ovarian tumor associated with a pulling sensation in the groin and histology showing bundles of spindle-shaped fibroblasts?

Answer: Ovarian Fibroma

Extra: • Clinical: Pulling sensation in groin. • Histology: Bundles of spindle-shaped fibroblasts. • Association: Meigs syndrome (Ovarian fibroma, Ascites, Hydrothorax).

Flashcard 8: What is the characteristic histological finding and cell type in a Brenner tumor?

Answer: "Coffee bean" nuclei; contains Walthard cell rests (transitional epithelium)

Extra: Brenner tumor: - Mostly benign ovarian surface epithelial tumor. - Histology: Characterized by "coffee bean" nuclei (longitudinal nuclear grooves) and nests of transitional epithelium (resembling bladder mucosa) called Walthard cell rests. - Gross: Solid, tan-white/yellow, well-encapsulated.

Flashcard 9: Is mucinous cystadenocarcinoma benign or malignant?

Answer: Malignant

Extra: Mucinous cystadenocarcinoma is the malignant counterpart of mucinous cystadenoma. It is a common primary surface epithelial tumor of the ovary, characterized by multiloculated cysts lined by atypically proliferated mucinous epithelium showing stromal invasion.

Flashcard 10: Morphological features of Mucinous Cystadenoma?

Answer: Multilocular cyst lined by mucus-secreting epithelium (Benign)

Extra: Mucinous cystadenomas are most commonly found in the ovary or pancreas. Characterized by large, multiloculated cysts filled with gelatinous fluid. Unlike serous cystadenomas, these are less likely to be bilateral in the ovary.

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DNA repair genes and cancer Flashcards for USMLE

Study 10 flashcards on DNA repair genes and cancer for USMLE Pathology. These active recall cards cover the key concepts, clinical associations, and high-yield facts from this chapter of Neoplasia. Each card is designed to test your understanding rather than just recognition, building stronger and more durable memories for exam day.

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There are 10 flashcards for DNA repair genes and cancer, covering the key concepts, clinical correlations, and high-yield facts from this chapter of Neoplasia.

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Read through each prompt and try to answer before revealing the back of the card. This active recall approach builds stronger memories than passive reading. Combine flashcards with the study notes and MCQ practice for the best results.

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Yes. This page covers one chapter of Neoplasia. Visit the topic page to see all chapters and their flashcards under Pathology.

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