Neoplasia — Flashcards

Flashcard 641: Myelodysplastic syndromes may present with _____ leukocytes and platelets

Answer: variable

Flashcard 642: An example of when the tumor staging factor of tumor size / invasiveness is the most important is in _____

Answer: Melanoma (Breslow Thickness)

Flashcard 643: What type of breast cancer may present with signet ring cells? _____

Answer: Lobular carcinoma (both in situ and invasive)

Flashcard 644: Carcinoma implies _____ origin, whereas Sarcoma denotes _____ origin

Answer: epithelial

Flashcard 645: Carcinoid tumor is a malignant proliferation of _____ cells; low-grade malignancy

Answer: neuroendocrine

Extra: Refer to endocrine section: Atlas:

Flashcard 646: Thyroid papillary carcinoma often spreads to the _____ nodes (lymphatic invasion)

Answer: cervical

Extra: * Medullary thyroid carcinoma Papillary thyroid carcinoma Micrograph image of thyroid tissue (H&E stain, 400x magnification) Green overlay: psammoma bodies White overlay: connective tissue core of papillae Black outline: epithelial cancer cells covering the papillae Atlas:

Flashcard 647: Myelodysplastic syndromes usually present with increased blasts _____%

Answer: < 20

Extra: Other:

Flashcard 648: WAGR syndrome is associated with a(n) _____ gene deletion

Answer: WT1

Extra: * Denys-Drash syndrome associated with a WT1 gene mutation Atlas:

Flashcard 649: Clonality can be determined via _____ isoforms in females

Answer: G6PD

Flashcard 650: Mutations in which proto-oncogene can lead to Colon Cancer, Non-Small Cell Lung Adenocarcinoma, and Pancreatic Cancer? _____

Answer: KRAS