Neoplasia — Flashcards

Flashcard 501: Which tumor suppressor genes are associated with breast, ovarian, fallopian and pancreatic cancer? _____

Answer: BRCA1/BRCA2

Extra: - These are involved in mediating dsDNA repair; BRCA 1 & 2 MCC familial pancreatic adenocarcinoma

Flashcard 502: Renal cell carcinoma commonly invades into the _____ (blood vessel)

Answer: renal vein

Flashcard 503: _____ tumors have features in between benign and malignant

Answer: Borderline

Flashcard 504: Which cancer is associated with Clonorchis sinensis infection? _____

Answer: Cholangiocarcinoma

Flashcard 505: Multiple myeloma presents with _____ bone lesions and hypercalcemia

Answer: lytic (punched-out)

Extra: Atlas: Other:

Flashcard 506: What is the most common malignant salivary gland tumor? _____

Answer: Mucoepidermoid carcinoma

Extra: Atlas:

Flashcard 507: In cervical pathology, a lesion involving the entire thickness of the epithelium but NOT penetrating the basement membrane is classified as: _____

Answer: Severely Dysplastic / Carcinoma in Situ

Flashcard 508: _____ is a serological antigen from EBV that contributes to Hodgkin's or Burkitt's Lymphoma

Answer: Epstein-Barr Nuclear Antigen (EBNA)

Flashcard 509: Hodgkin lymphoma is associated with _____ infection

Answer: EBV

Extra: Atlas: Other:

Flashcard 510: The microsatellite instability pathway of colorectal cancer is characterized by mutations or methylation of _____ genes

Answer: mismatch repair

Extra: * (Lynch Syndrome) Colorectal carcinogenesis pathways Top: Chromosomal instability pathway (adenoma-carcinoma sequence) - Loss of the tumor suppressor gene, APC, results in hyperproliferative epithelium due to a loss of cellular adhesion and increased cellular proliferation. A mutation in KRAS results in unregulated cellular signaling and cellular proliferation, leading to the formation of an adenoma. Loss of the tumor suppressor genes TP53 and DCC results in the malignant transformation of an adenoma to carcinoma. The chromosomal instability pathway is responsible for carcinomas in FAP (loss of APC) as well as in most cases of sporadic colorectal carcinoma. Bottom: Microsatellite instability pathway - Acquired or inherited mutations in the mismatch repair genes (esp. MLH1 and MSH2) result in abnormal proliferation and the formation of adenoma and carcinoma. The microsatellite instability pathway is responsible for carcinomas in Lynch syndrome (HNPCC) and a few cases of sporadic colorectal carcinoma. Atlas: