Neoplasia — Flashcards

Flashcard 491: The MYCC _____ encodes for the nuclear regulator c-myc, which stimulates cell cycle progression

Answer: proto-oncogene

Flashcard 492: Is polycythemia vera associated with JAK2 mutations? _____

Answer: Yes

Extra: * V617F is the most common mutation Other:

Flashcard 493: Which thyroid malignancy may arise sporadically or from progression of papillary or follicular carcinoma? _____

Answer: Anaplastic thyroid carcinoma

Extra: *May arise from papillary or follicular carcinoma via p53 gene mutations

Flashcard 494: In the treatment of Giant Cell Tumor Of Bone, Denosumab works by binding _____, which inhibits the recruitment and activation of multinucleated giant cells.

Answer: RANKL

Extra: Denosumab is a monoclonal antibody against RANKL; it mimics the action of osteoprotegerin. Note: In Giant Cell Tumor of Bone (GCTOB), the neoplastic stromal cells express RANKL, which then recruits and activates the reactive multinucleated giant cells (which express RANK). Links:

Flashcard 495: Females with BRCA1 mutations have increased risk for which types of cancer? _____

Answer: Breast, ovarian, and fallopian tube

Extra: - These are involved in mediating dsDNA repair; BRCA 1 & 2 MCC familial pancreatic adenocarcinoma

Flashcard 496: A malignant mesenchymal tumor is a(n) _____

Answer: sarcoma

Flashcard 497: Giant cell tumor is a locally aggressive _____ tumor

Answer: benign

Flashcard 498: Which cancer is associated with Clonorchis sinensis infection? _____

Answer: Cholangiocarcinoma

Flashcard 499: Cervical carcinoma is an invasive carcinoma that arises from the cervical epithelium and invades through the _____

Answer: basement membrane

Flashcard 500: _____ tumors have features in between benign and malignant

Answer: Borderline