Neoplasia — Flashcards

Flashcard 1411: In lymphoma (a monoclonal B-cell proliferation), the normal 3:2 kappa:lambda light chain ratio will _____

Answer: change (become skewed)

Extra: Normal B-cell populations are polyclonal, maintaining a kappa:lambda ratio of approximately 3:1 (or 3:2). Neoplastic proliferations (lymphoma) are monoclonal, meaning all cells express the same light chain, which results in a skewed ratio (e.g., >6:1 or <1:3).

Flashcard 1412: Which Herpesvirus is associated with Hodgkin Lymphoma?_____

Answer: EBV

Flashcard 1413: _____ is a neoplastic proliferation of Langerhans cells

Answer: Langerhans cell histiocytosis

Flashcard 1414: Is hairy leukoplakia pre-malignant for oral squamous cell carcinoma? _____

Answer: No

Flashcard 1415: Does the vertical phase of melanoma growth have a high risk of metastasis? _____

Answer: Yes

Flashcard 1416: _____ are pancreatic neuroendocrine tumors that are associated with psammoma bodies.

Answer: Somatostatinomas

Flashcard 1417: Reed-Sternberg cells secrete _____, which attract other inflammatory cells

Answer: cytokines

Flashcard 1418: Grade _____ follicular lymphoma is characterized by small cleaved cells

Answer: 1

Flashcard 1419: Loss of p53 is seen in >_____% of cancers

Answer: 50

Flashcard 1420: Does HCV increase the risk of hepatocellular carcinoma?_____

Answer: Yes