Neoplasia — Flashcards

Flashcard 1421: If DNA repair is not possible, p53 induces _____

Answer: apoptosis

Flashcard 1422: Burkitt lymphoma is associated with _____ infection

Answer: EBV

Flashcard 1423: _____ is the single most important prognostic factor for a cancer

Answer: Metastasis (M)

Flashcard 1424: Follicular lymphoma may progress to _____ lymphoma, which presents as an enlarging lymph node

Answer: diffuse, large B-cell

Flashcard 1425: Grade _____ follicular lymphoma is characterized by small cleaved cells

Answer: 1

Flashcard 1426: In lymphoma (a monoclonal B-cell proliferation), the normal 3:2 kappa:lambda light chain ratio will _____

Answer: change (become skewed)

Extra: Normal B-cell populations are polyclonal, maintaining a kappa:lambda ratio of approximately 3:1 (or 3:2). Neoplastic proliferations (lymphoma) are monoclonal, meaning all cells express the same light chain, which results in a skewed ratio (e.g., >6:1 or <1:3).

Flashcard 1427: What astrocyte-derived CNS tumor is associated with tuberous sclerosis?_____

Answer: Subependymal giant cell astrocytomas

Flashcard 1428: Which form of Burkitt's lymphoma presents as a mass on the jaw or face?_____

Answer: Endemic (African)

Flashcard 1429: Which oncogene is associated with Neuroblastoma?_____

Answer: N-myc overexpression

Flashcard 1430: What mutation is common in endometrial carcinoma from the sporadic pathway?_____

Answer: p53 mutations