Central Nervous System Pharmacology — Flashcards

Flashcard 161: Aducanumab and Lecanemab are anti- _____ monoclonal antibodies used for treatment of Alzheimer's disease

Answer: Amyloid-beta (Aβ)

Flashcard 162: Use of morphine is contraindicated in head trauma as it can lead to increased _____

Answer: ICP

Flashcard 163: _____ are the most effective group of drugs in the prevention of emergence reactions following ketamine

Answer: Benzodiazepines

Flashcard 164: Affective flattening due to antipsychotics occurs because of their action on _____ receptors

Answer: D2

Flashcard 165: Zonisamide is a _____-spectrum antiepileptic

Answer: broad

Flashcard 166: _____ is a partial agonist of 5-HT1A  receptors, used for treatment of hypoactive sexual desire disorder in women

Answer: Flibanserin

Flashcard 167: Which antiepileptic is used in partial seizures due to its ability to act on neuronal potassium channels?_____

Answer: Ezogabine/Retigabine

Flashcard 168: _____ subunit of the GABAA receptors produces sedation, anterograde amnesia and anticonvulsant action

Answer: Alpha-1 (α1)

Flashcard 169: Which nerve fibers are the most susceptible to local anesthetics?

Answer: Type B fibers (preganglionic sympathetic)

Extra: The order of susceptibility to local anesthetic (LA) blockade is: **Type B > Type C > Type Aδ > Type Aγ > Type Aβ > Type Aα**. **Key Principles:** 1. **Diameter:** Smaller fibers are generally more susceptible than larger fibers. 2. **Myelination:** For fibers of the same diameter, myelinated fibers are blocked more easily than unmyelinated ones. (This explains why myelinated **B fibers** are more sensitive than unmyelinated **C fibers**). **Clinical Sequence of Blockade:** 1. Sympathetic blockade (B fibers) 2. Pain, temperature (C and Aδ fibers) 3. Proprioception, touch, pressure (Aβ and Aγ) 4. Motor (Aα)

Flashcard 170: Which tetracycline is used for short-term improvements in anxiety, mood, and the Clinical Global Impression Scale in Fragile X syndrome?_____

Answer: Minocycline