Autonomic/CV Drugs — Flashcards

Flashcard 2781: Which of the topoisomerase inhibitors (2) are associated with severe diarrhea?_____

Answer: irinotecan, topotecan

Flashcard 2782: Patients on nitrates have a nitrate-free interval everyday to prevent _____

Answer: tolerance

Flashcard 2783: Fibrates lead to _____ in serum LDL by reducing VLDL

Answer: mild decreases

Flashcard 2784: Digitalis toxicity may induce _____, such as premature ventricular contractions

Answer: arrhythmias

Flashcard 2785: Are 2nd generation H1 receptor antagonists associated with drowsiness? _____

Answer: No (do not cross BBB therefore less sedation)

Flashcard 2786: _____ is a long-acting oral opioid used for opioid detoxification or long-term maintenance therapy

Answer: Methadone

Extra: Methadone is a potent, long-acting full mu-opioid agonist with good oral bioavailability, making it ideal for maintenance therapy. Buprenorphine is a partial mu-opioid agonist and is typically administered sublingually (due to high first-pass metabolism) for the same indications.

Flashcard 2787: Do opiates have addictive potential? _____

Answer: Yes

Flashcard 2788: What drug class does exemestane belong to?_____

Answer: Aromatase inhibitor

Flashcard 2789: GLP-1 agonists and DPP-4 inhibitors cause decreased _____ secretion

Answer: glucagon

Flashcard 2790: Are class IC antiarrhythmics used to treat supraventricular or ventricular arrhythmias?_____

Answer: Both