Autonomic/CV Drugs — Flashcards

Flashcard 2501: Statins indirectly cause _____ LDL receptor expression on hepatocytes

Answer: increased

Flashcard 2502: Which Ca2+ channel blocker has the most potent effects on cardiac muscle? _____

Answer: Verapamil

Flashcard 2503: What is the effect of glucocorticoids on production of phospholipase A2?_____

Answer: Decreased (inhibition)

Flashcard 2504: Patients with _____ have increased risk for metformin-induced lactic acidosis due to metformin accumulation

Answer: renal insufficiency

Flashcard 2505: What drug class do cholestyramine, colestipol, and colesevelam belong to?

Answer: Bile acid resins

Flashcard 2506: What effect does a partial agonist have on efficacy?_____

Answer: Decrease (curve shifts down)

Flashcard 2507: What two cholesterol modulating medications should not be combined due to a high risk of causing rhabdomyolysis?_____

Answer: Statins + Fibrates

Flashcard 2508: Compared to full agonists, partial agonists have _____ efficacy

Answer: less

Flashcard 2509: Vincristine is associated with autonomic dysfunction, specifically _____ and constipation

Answer: paralytic ileus

Flashcard 2510: ACE inhibitors, Beta-blockers (compensated HF), and Aldosterone Antagonists are beneficial in Heart Failure because they help prevent:

Answer: Cardiac remodeling

Extra: These drug classes (ACE inhibitors, Beta-blockers, and Aldosterone Antagonists) have been shown to reduce mortality in patients with heart failure by preventing or reversing maladaptive cardiac remodeling.