Autonomic/CV Drugs — Flashcards

Flashcard 2451: Etanercept works by complexing with TNF-a and inducing _____ of the complex

Answer: phagocytosis

Flashcard 2452: Which Ca2+ channel blocker has the most potent effects on cardiac muscle? _____

Answer: Verapamil

Flashcard 2453: What drugs (2) may be used to treat Granulomatosis with polyangiitis?_____

Answer: Cyclophosphamide, corticosteroids

Flashcard 2454: Statins indirectly cause _____ LDL receptor expression on hepatocytes

Answer: increased

Flashcard 2455: Bile acid resins are used in patients with primary _____, usually in conjunction with statins

Answer: hypercholesterolemia

Flashcard 2456: On an FA/FI (alveolar to inspired concentration) curve, does an inhaled anesthetic with **high blood solubility** show a fast or slow rate of rise?

Answer: High (e.g., halothane)

Extra: High blood solubility means the blood acts as a large reservoir, "soaking up" the anesthetic and delaying the rise in alveolar partial pressure (FA). Therefore, higher solubility results in a slower rate of rise in the FA/FI ratio and slower induction.

Flashcard 2457: Glucocorticoids prevent production of _____ by inhibiting phospholipase A2

Answer: arachidonic acid

Flashcard 2458: Tacrolimus can cause a _____glycemia

Answer: hyper

Flashcard 2459: Which antitumor monoclonal antibody is associated with heart failure (cardiotoxicity)?_____

Answer: trastuzumab (herceptin)

Flashcard 2460: What effect does ranolazine have on heart rate and contractility?_____

Answer: No effect