Autonomic/CV Drugs — Flashcards

Flashcard 2371: Calcitriol is useful in the long term management of _____ due to chronic disorders

Answer: hypocalcemia

Flashcard 2372: What drug class does duloxetine belong to?_____

Answer: SNRIs

Flashcard 2373: Rituximab is an antitumor monoclonal antibody that targets _____ of B-cells

Answer: CD20

Flashcard 2374: Most loop diuretics are _____ drugs and thus may cause adverse reactions in allergic patients

Answer: sulfa

Flashcard 2375: What drug intoxication presents as pupillary dilation, grandiosity, hypertension, and paranoia that lasts for multiple hours? _____

Answer: Amphetamines

Flashcard 2376: Sudden discontinuation of SSRIs or SNRIs can cause _____-like symptoms

Answer: flu

Flashcard 2377: Safer drugs have a _____ therapeutic index value

Answer: higher

Flashcard 2378: What effect do dihydropyridine CCBs have on afterload?_____

Answer: Decreased afterload (via peripheral vasodilation)

Flashcard 2379: Calcium Channel Blockers (CCBs) Dihydropyridine CCBs have a _____ suffix

Answer: -dipine

Flashcard 2380: NSAIDs increase the risk of GI bleeding primarily through the inhibition of which enzyme?

Answer: COX-1

Extra: Inhibition of **COX-1** leads to: 1. Decreased **PGE2 and PGI2**: Reduces gastric mucosal protection (decreases mucus and bicarbonate secretion, decreases blood flow). 2. Decreased **TXA2**: Inhibits platelet aggregation, which increases the tendency to bleed from any mucosal damage.