Autonomic/CV Drugs — Flashcards

Flashcard 2371: Calcitriol is useful in the long term management of _____ due to chronic disorders

Answer: hypocalcemia

Flashcard 2372: SSRIs can cause weight _____

Answer: gain

Flashcard 2373: What drug class does duloxetine belong to?_____

Answer: SNRIs

Flashcard 2374: Which thyroid medications are associated with drug-induced lupus?_____

Answer: Propylthiouracil (PTU), methimazole

Flashcard 2375: Which NSAID is a sulfa drug? _____

Answer: Celecoxib

Flashcard 2376: What effect do class IB antiarrhythmics have on action potential duration? _____

Answer: Shortened duration

Flashcard 2377: NSAIDs increase the risk of GI bleeding primarily through the inhibition of which enzyme?

Answer: COX-1

Extra: Inhibition of **COX-1** leads to: 1. Decreased **PGE2 and PGI2**: Reduces gastric mucosal protection (decreases mucus and bicarbonate secretion, decreases blood flow). 2. Decreased **TXA2**: Inhibits platelet aggregation, which increases the tendency to bleed from any mucosal damage.

Flashcard 2378: Irinotecan and topotecan can result in _____-suppression

Answer: myelo

Flashcard 2379: What are 2nd generation H1 receptor antagonists used to treat? _____

Answer: Allergies

Flashcard 2380: Cardiac glycosides (e.g. digoxin) exert their effects via inhibition of the _____ pump

Answer: Na+-K+ ATPase