Autonomic/CV Drugs — Flashcards

Flashcard 2221: What is the most common cause of death in tricyclic antidepressant overdose? _____

Answer: Fatal cardiac arrhythmia

Flashcard 2222: What effect do thiazide diuretics have on serum Ca2+ levels? _____

Answer: Increased

Flashcard 2223: Pharmacology: In fat, stimulation of B3 receptors results in _____

Answer: increased lipolysis

Flashcard 2224: What is a possible skin complication associated with amiodarone?

Answer: Blue-gray skin discoloration (hyperpigmentation)

Extra: Amiodarone is a class III antiarrhythmic. It is associated with several high-yield side effects: - **Pulmonary fibrosis** (most serious) - **Thyroid dysfunction** (hypo- or hyperthyroidism, due to its high iodine content) - **Hepatotoxicity** - **Corneal microdeposits** - **Blue-gray skin discoloration** (photodermatitis resulting in hyperpigmentation)

Flashcard 2225: Which thyroid medications are associated with aplastic anemia?_____

Answer: Propylthiouracil (PTU) and methimazole

Flashcard 2226: Do inhaled corticosteroids present with the typical adverse effects of corticosteroid therapy? _____

Answer: No, minimal systemic absorption

Flashcard 2227: Treatment of acute coronary syndromes often includes _____ inhibitors to decrease left ventricular dilation

Answer: ACE

Flashcard 2228: Which chronic gout drug must be administered IV?_____

Answer: Pegloticase

Flashcard 2229: What is the relative volume of distribution (Vd) of a plasma protein-bound molecule? _____

Answer: Low

Flashcard 2230: Benzodiazepines can cause dose-dependent _____-grade amnesia

Answer: antero