Autonomic/CV Drugs — Flashcards

Flashcard 2221: What is the route of administration of leukotriene D4-receptor antagonists (e.g. montelukast, zafirlukast)? _____

Answer: Oral administration

Flashcard 2222: What effect do class IC antiarrhythmics have on the effective refractory period in the AV node and accessory bypass tracts?_____

Answer: Significant prolongation of ERP

Flashcard 2223: Do inhaled corticosteroids present with the typical adverse effects of corticosteroid therapy? _____

Answer: No, minimal systemic absorption

Flashcard 2224: One possible treatment for digoxin toxicity is _____ fragments

Answer: anti-digoxin Fab

Flashcard 2225: Class III antiarrhythmics may be used to treat _____ fibrillation (and flutter)

Answer: atrial

Flashcard 2226: Do most NSAIDs reversibly or irreversibly inhibit COX-1 and COX-2?_____

Answer: Reversibly (except aspirin)

Flashcard 2227: Treatment of acute coronary syndromes often includes _____ inhibitors to decrease left ventricular dilation

Answer: ACE

Flashcard 2228: What is a possible skin complication associated with amiodarone?

Answer: Blue-gray skin discoloration (hyperpigmentation)

Extra: Amiodarone is a class III antiarrhythmic. It is associated with several high-yield side effects: - **Pulmonary fibrosis** (most serious) - **Thyroid dysfunction** (hypo- or hyperthyroidism, due to its high iodine content) - **Hepatotoxicity** - **Corneal microdeposits** - **Blue-gray skin discoloration** (photodermatitis resulting in hyperpigmentation)

Flashcard 2229: Theophylline can cause _____ (HR)

Answer: tachycardia

Flashcard 2230: Clomiphene results in _____ release of FSH and LH from the pituitary

Answer: increased