Autonomic/CV Drugs — Flashcards

Flashcard 1101: What kind of drug is ketotifen? _____

Answer: 2nd-gen antihistamine and mast cell stabilizer

Flashcard 1102: _____ and _____ = inhibited reuptake of dopamine and norepinephrine

Answer: Cocaine

Flashcard 1103: What is the preferred adjuvant treatment for ER+ breast cancer in postmenopausal women? _____

Answer: Aromatase inhibitors (e.g. anastrozole)

Extra:  https://onlinemeded.org/spa/surgery?ref=anki 

Flashcard 1104: Opioids and other CNS depressants can cause _____ by inducing impaired consciousness with prolonged immobilization and ischemic compression

Answer: rhabdomyolysis

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 1105: Starting _____ may lead to breakthrough bleeding

Answer: OCPs

Extra:  https://onlinemeded.org/spa/obgyn?ref=anki 

Flashcard 1106: What is a physiological reason for the decreased phenytoin concentration in a pregnant patient? _____

Answer: Pregnancy → ↑ hepatic metabolism and renal clearance → ↓ phenytoin concentration

Extra: During pregnancy, increased hepatic CYP metabolism (induction) and increased renal blood flow/GFR lead to increased clearance of phenytoin. Total phenytoin levels also appear lower due to the physiological hypoalbuminemia of pregnancy (decreased protein binding), though the active free fraction is what is clinically monitored. https://onlinemeded.org/spa/obstetrics/medical-disease/acquire?ref=anki

Flashcard 1107: Is carbamazepine use associated with teratogenic effects? _____

Answer: Yes

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 1108: Statins may cause mild _____-toxicity, and thus mild elevations in _____ function tests

Answer: hepato

Extra:  https://onlinemeded.org/spa/cardiology/cholesterol/acquire?ref=anki 

Flashcard 1109: Deferoxamine, deferasirox, and deferiprone = _____

Answer: iron chelators

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 1110: Patient with coronary artery disease and acute migraine refractory to NSAIDs = _____

Answer: prochlorperazine/metoclopramide (D2 antagonist)

Extra:  https://onlinemeded.org?ref=anki