Antimicrobials — Flashcards

Flashcard 791: Which strain(s) of Plasmodium is primaquine used to treat?_____

Answer: Plasmodium vivax/ovale

Flashcard 792: Nitrosoureas cross the blood-brain barrier and can thus treat brain tumors (ie: _____)

Answer: glioblastoma multiforme

Flashcard 793: Methotrexate is associated with _____ (oral pathology)

Answer: mucositis

Flashcard 794: Administration of 5-fluorouracil results in a build-up of _____ in cells

Answer: dUMP

Flashcard 795: How should loading dose be adjusted in patients with renal or liver disease? _____

Answer: Unchanged

Flashcard 796: 5-fluorouracil is known to cause _____ (palmar-plantar erythrodysesthesia).

Answer: Hand-foot syndrome

Extra: Other drugs commonly associated with hand-foot syndrome (palmar-plantar erythrodysesthesia) include: - Capecitabine (a prodrug of 5-FU) - Cytarabine - Liposomal Doxorubicin - Multikinase inhibitors (e.g., Sorafenib, Sunitinib)

Flashcard 797: Which chemotherapeutic drug can cause hand-foot syndrome (palmar-plantar erythrodysesthesia)?_____

Answer: 5-fluorouracil

Flashcard 798: Which drug is taken weekly for malaria prophylaxis in travelers to areas with chloroquine-resistant Plasmodium falciparum?

Answer: Mefloquine

Flashcard 799: Which gout drug prevents renal excretion of drugs (ie: penicillin; cidofovir)?_____

Answer: Probenecid

Flashcard 800: _____, tetracyclines, and vitamin A may cause idiopathic intracranial hypertension as an adverse effect.

Answer: Growth hormone