Antimicrobials — Flashcards

Flashcard 791: Polysaccharide vaccines are conjugated to a _____ to elicit a stronger, T-cell dependent immune response and immunologic memory.

Answer: protein (carrier protein)

Flashcard 792: What drug is used to reverse methotrexate toxicity?_____

Answer: Leucovorin

Flashcard 793: Vemurafenib is used to treat metastatic melanoma that has a BRAF _____ mutation

Answer: V600E or V600K (2 mutations #)

Flashcard 794: Which ulcerative colitis drug is associated with reversible oligospermia?_____

Answer: Sulfasalazine

Flashcard 795: What enzyme is necessary for activation of 6-mercaptopurine?_____

Answer: HGPRT

Flashcard 796: How should loading dose be adjusted in patients with renal or liver disease? _____

Answer: Unchanged

Flashcard 797: 5-fluorouracil is known to cause _____ (palmar-plantar erythrodysesthesia).

Answer: Hand-foot syndrome

Extra: Other drugs commonly associated with hand-foot syndrome (palmar-plantar erythrodysesthesia) include: - Capecitabine (a prodrug of 5-FU) - Cytarabine - Liposomal Doxorubicin - Multikinase inhibitors (e.g., Sorafenib, Sunitinib)

Flashcard 798: Which chemotherapeutic drug can cause hand-foot syndrome (palmar-plantar erythrodysesthesia)?_____

Answer: 5-fluorouracil

Flashcard 799: Which drug is taken weekly for malaria prophylaxis in travelers to areas with chloroquine-resistant Plasmodium falciparum?

Answer: Mefloquine

Flashcard 800: Which gout drug prevents renal excretion of drugs (ie: penicillin; cidofovir)?_____

Answer: Probenecid