Antimicrobials — Flashcards

Flashcard 541: Which chemotherapeutic drug is used in bone marrow ablation prior to marrow transplant?_____

Answer: Busulfan

Flashcard 542: Which phase of drug metabolism is lost first in geriatric patients? _____

Answer: Phase I

Flashcard 543: Are NSAIDs useful as anti-inflammatory agents?_____

Answer: Yes

Flashcard 544: Toxocara canis is treated with _____

Answer: albendazole

Flashcard 545: 5-fluorouracil is a prodrug that is converted to its active form _____

Answer: 5-fdUMP

Flashcard 546: Which types of vaccines usually requires booster shots?_____

Answer: Killed/inactivated vaccine

Flashcard 547: Vincristine and vinblastine can result in _____ (hair pathology)

Answer: alopecia

Flashcard 548: Which of the platinum analogs is most commonly associated with myelosuppression?

Answer: Carboplatin

Flashcard 549: In patients taking ruxolitinib, an important side effect is _____toxicity

Answer: hemato

Extra: Ruxolitinib is a JAK1/JAK2 inhibitor used in the treatment of myelofibrosis and polycythemia vera. Its primary dose-limiting side effects are **hematologic toxicities**, specifically **anemia** and **thrombocytopenia**. While mild LFT elevations can occur, "hematotoxicity" is the high-yield side effect for medical examinations.

Flashcard 550: Which DNA polymerase inhibiting pyrimidine analog is used to treat both hematologic malignancies and solid tumors?_____

Answer: Gemcitabine