Antimicrobials — Flashcards

Flashcard 211: Methotrexate can result in _____

Answer: alopecia

Flashcard 212: Testing for "_____" in adenocarcinoma of the lung guides systemic therapy in advanced disease

Answer: driver mutations

Flashcard 213: Which chemotherapeutic drug is used to wean patients off steroids in chronic disease? _____

Answer: Azathioprine/6-MP

Flashcard 214: Pembrolizumab is indicated for the treatment of _____ that are MSI-H or dMMR

Answer: all solid tumors

Extra: Pembrolizumab and nivolumab are PD-1 inhibitors. They are used for various cancers (melanoma, NSCLC, RCC) and have a tissue-agnostic indication for MSI-H (microsatellite instability-high) or dMMR (deficient mismatch repair) solid tumors.

Flashcard 215: Which antitumor monoclonal antibody targets epidermal growth factor receptor? _____

Answer: Cetuximab

Flashcard 216: Canakinumab is a biologic that binds and prevents the activity of IL-_____

Answer: 1B

Flashcard 217: What is the effect of glucocorticoids on blood lymphocyte levels? _____

Answer: Decreased (especially T-helper cells)

Extra: Sketchy Pharmacology: Thyroid, Pituitary, & Adrenal

Flashcard 218: Cisplatin targets the _____ cells within the _____, resulting in tinnitus and sensorineural hearing loss

Answer: outer hair

Flashcard 219: "Busulfan Lung" is the term for the _____ pattern of lung damage which can be caused by Busulfan

Answer: fibrotic

Flashcard 220: Anthracyclines (-rubicin) bind _____ to cause cleavage of DNA

Answer: topoisomerase II