Antimicrobials — Flashcards

Flashcard 161: Vincristine and vinblastine can result in _____

Answer: alopecia

Flashcard 162: An _____ refers to adverse actions that occur due to known pharmacologic actions of the drug but at a lower dose than expected

Answer: exaggerated drug sensitivity

Flashcard 163: Azathioprine/6MP are used to treat chronic inflammatory diseases that are refractory to _____

Answer: corticosteroids

Flashcard 164: Cytarabine is a cytotoxic _____ analog

Answer: pyrimidine

Flashcard 165: Cladribine is a DNA polymerase inhibitor that treats _____ leukemia

Answer: hairy cell

Flashcard 166: Nitazoxanide can be used to treat _____

Answer: Cryptosporidium

Flashcard 167: What drugs are used to treat toxoplasmosis (toxoplasma gondii)? _____

Answer: Pyrimethamine/Sulfadiazine

Flashcard 168: Cytarabine is a pyrimidine analog indicated for _____ as well as non-Hodgkin's Lymphoma

Answer: leukemias

Extra: Cytarabine (ara-C) is a pyrimidine analog that inhibits DNA polymerase. It is a backbone of treatment for AML (the "7" in "7+3" induction). Key indications: 1. Leukemias (AML, ALL) 2. Non-Hodgkin Lymphoma (high-grade) Note: Do not confuse with Cladribine, which specifically targets lymphocytes and is the drug of choice for Hairy Cell Leukemia.

Flashcard 169: Taxanes can cause a peripheral sensory neuropathy as well as induce _____ reactions

Answer: hypersensitivity

Flashcard 170: Which chemotherapeutic drugs are associated with nephrotoxicity, ototoxicity, and peripheral neuropathy? _____

Answer: Platinum analogs