Systemic Pathology — Flashcards

Flashcard 291: PSGN may display _____ infiltrate in the mesangium and endothelium on light microscopy

Answer: leukocyte (lots of nuclei present)

Flashcard 292: Osteogenesis imperfecta is most commonly caused by gene defects in _____ and _____

Answer: COL1A1

Extra: - It usually results from autosomal dominant mutations in the genes that encode the α1 and α2 chains of type I collagen - These defects cause misfolding of the mutated collagen polypeptides, and they interfere with the proper assembly of wild-type collagen chains (a dominant negative loss of function)

Flashcard 293: What HLA subtypes are associated with Addison disease? _____, DR3, and DR4

Answer: B8

Flashcard 294: Psoriasis is associated with _____ thickness of the stratum granulosum

Answer: decreased

Flashcard 295: Fatty casts ("oval fat bodies") are often associated with the "_____" sign

Answer: Maltese cross

Extra: Step Up to Medicine: Other: Goljan:

Flashcard 296: What HLA subtype is associated with Goodpasture syndrome? _____

Answer: DR2

Flashcard 297: Nephritic syndrome occurs due to _____ disruption

Answer: GBM

Extra: Step Up to Medicine:

Flashcard 298: Pathogenesis of _____ involves activation of the humoral immune response, cellular immune response, and complement cascade

Answer: Guillain-Barré syndrome

Extra:  

Flashcard 299: Subacute granulomatous thyroiditis is thought to involve HLA-_____ polymorphisms and viral infection

Answer: B35

Extra: * HLA-B35 & viral infection -> molecular mimicry -> recognition of self antigens in the thyroid -> autoimmune destruction of thyroid. Note: Subacute granulomatous thyroiditis is also known as De Quervain thyroiditis. It typically follows a viral upper respiratory infection and presents with a painful, tender thyroid.

Flashcard 300: What is the third stage of Paget disease of bone (osteitis deformans)? _____

Answer: Osteoblastic (sclerotic)

Extra: Atlas: