Systemic Pathology — Flashcards

Flashcard 301: Pemphigus vulgaris is due to IgG antibodies against _____

Answer: desmoglein

Extra: Atlas: Desmosomes (desmogleins 1 & 3) versus the basement membrane (hemidesmosomes) targeted in bullous pemphigoid (bullow, below)

Flashcard 302: Goodpasture syndrome occurs due to antibodies against the _____ and _____ basement membranes

Answer: glomerular

Extra: Atlas: autoantibodies against type IV collagen type 2 x type 2 = type 4 collagen sx: hematuria (glomerulus) + hemoptysis (alveoli)

Flashcard 303: Death from Filoviruses (ebola, marburg) results from _____ shock

Answer: hemorrhagic (hypovolemic)

Flashcard 304: Holoprosencephaly may be related to mutations in the _____ signaling pathway

Answer: sonic hedgehog

Flashcard 305: Polyarteritis nodosa is characterized by innumerable renal _____ and spasms on arteriogram

Answer: microaneurysms

Extra: Atlas:

Flashcard 306: What endocrine pathology may cause renal papillary necrosis? _____

Answer: Diabetes mellitus

Extra: Atlas:

Flashcard 307: _____ are the most common changes in pre-menopausal breast

Answer: Fibrocystic changes

Flashcard 308: _____ osteoporosis is characterized by normal osteoclast activity with decreased osteoblast activity

Answer: Type 2 ('senile')

Flashcard 309: What type of hydrocephalus may be seen with Alzheimer disease? _____

Answer: Hydrocephalus ex vacuo

Extra: Atlas:

Flashcard 310: _____ glomerulonephritis is a nephritic syndrome that progresses to renal failure in days to weeks

Answer: Rapidly progressive

Extra: Robbins: