Systemic Pathology US Medical PG Flashcards - Medical Study Cards
Master Systemic Pathology with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Systemic Pathology Flashcard Deck - 10 Cards
Flashcard 1: What is the enzyme deficiency and accumulated substrate in Niemann-Pick disease?
Answer: Lysosomal storage disease caused by a deficiency in sphingomyelinase, leading to accumulation of sphingomyelin.
Extra: • Clinical Features: Progressive neurodegeneration, hepatosplenomegaly, and cherry-red spot on macula.
• Pathology: Foam cells (lipid-laden macrophages) are characteristic.
• Genetics: Autosomal recessive (AR).
• Population: Increased frequency in Ashkenazi Jews.
*Distinction: Unlike Tay-Sachs, Niemann-Pick presents with hepatosplenomegaly.*
Flashcard 2: Gaucher's disease
Answer:
Extra: accumulation of glucocerebroside hepatosplenomegaly, aseptic necrosis of femur, bone crises crumpled-paper cells
Ashkenazi Jew AR glucocerebrosidase
Flashcard 3: Patau's syndrome
Answer: Trisomy 13
Key features: Microphthalmia, Microcephaly, Cleft lip/palate, Polydactyly, Holoprosencephaly, and Rocker-bottom feet.
Extra: First trimester pregnancy screen:
- Decreased β-hCG
- Decreased PAPP-A
- Ultrasound: Increased nuchal translucency
Note: Most cases result in death within the first year of life.
Flashcard 4: In metachromatic leukodystrophy, sulfatides accumulate in the lysosomes of _____
Answer: oligodendrocytes
Extra:
https://onlinemeded.org/spa/metabolism?ref=anki
Atlas:
Flashcard 5: _____ is characterized histologically by acanthosis with parakeratosis
Answer: Psoriasis
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/dermatology/videos/inflammatory-diseases-of-the-skin?index=10]
https://onlinemeded.org/spa/musculoskeletal/inflammatory-dermatoses/acquire?ref=anki
Atlas:
Flashcard 6: What type of cast may be seen in end-stage renal disease and chronic renal failure?
_____
Answer: Waxy casts
Extra:
Watch Chronic Kidney Disease (CKD) [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-renal/videos/medical-pathophysiology-renal-congenital-and-chronic-kidney-disease-chronic-kidney-disease-ckd?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/nephrology/videos/pathology-diagnostics?index=6]
https://onlinemeded.org/spa/nephrology/acute-kidney-injury/acquire?ref=anki
Step Up to Medicine:
Other:
Goljan:
Flashcard 7: Dialysis-associated amyloidosis is characterized by deposition of _____ in joints
Answer: β2-microglobulin
Extra:
Watch Amyloidosis [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-immunology/videos/medical-pathophysiology-immunology-autoimmune-and-amyloidosis-amyloidosis?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/immunology?ref=anki
Flashcard 8: DIC typically presents with increased _____ split products, particularly D-dimer
Answer: fibrin
Extra:
Watch Acquired Coagulation Defects [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-blood-coagulation/videos/medical-pathophysiology-blood-and-coagulation-coagulopathies-and-platelet-disorders-acquired-coagulation-defects?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/coagulation-and-fibrinolysis?index=9]
https://onlinemeded.org/spa/heme-onc/hemostasis/acquire?ref=anki
Flashcard 9: What type of cast may be seen with transplant rejection and tubulointerstitial inflammation?
_____
Answer: WBC casts
Extra:
Watch Nephritic Syndrome [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-renal/videos/medical-pathophysiology-renal-glomerulopathy-nephritic-syndrome?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/nephrology/videos/pathology-diagnostics?index=6]
https://onlinemeded.org/spa/nephrology/acute-kidney-injury/acquire?ref=anki
Step Up to Medicine:
Other:
Goljan:
Flashcard 10: IgA nephropathy is characterized by _____ immune complex deposits on electron microscopy
Answer: mesangial
Extra:
Watch Nephritic Syndrome [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-renal/videos/medical-pathophysiology-renal-glomerulopathy-nephritic-syndrome?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/nephrology/videos/nephritic-syndromes?index=6]
https://onlinemeded.org/spa/renal/nephritic-syndrome/acquire?ref=anki
Atlas:
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