Skeletal muscle diseases US Medical PG Flashcards - Medical Study Cards
Master Skeletal muscle diseases with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Skeletal muscle diseases Flashcard Deck - 10 Cards
Flashcard 1: What vasculitis is a granulomatous, necrotizing vasculitis with eosinophilia?_____
Answer: Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis)
Flashcard 2: Non-enzymatic glycosylation of small vessels may cause nodular _____ with Kimmelstiel-Wilson nodules; may cause chronic renal failure
Answer: glomerulosclerosis
Flashcard 3: Which blistering skin disorder is characterized by fever and sloughing of skin at the dermal-epidermal junction? _____
Answer: Stevens-Johnson syndrome
Flashcard 4: X-linked muscular dystrophy is characterized by muscle wasting and replacement of skeletal muscle by _____ tissue
Answer: adipose
Flashcard 5: What is the enzyme deficiency and accumulated substrate in Niemann-Pick disease?
Answer: Lysosomal storage disease caused by a deficiency in sphingomyelinase, leading to accumulation of sphingomyelin.
Extra: • Clinical Features: Progressive neurodegeneration, hepatosplenomegaly, and cherry-red spot on macula.
• Pathology: Foam cells (lipid-laden macrophages) are characteristic.
• Genetics: Autosomal recessive (AR).
• Population: Increased frequency in Ashkenazi Jews.
*Distinction: Unlike Tay-Sachs, Niemann-Pick presents with hepatosplenomegaly.*
Flashcard 6: Gaucher's disease
Answer:
Extra: accumulation of glucocerebroside hepatosplenomegaly, aseptic necrosis of femur, bone crises crumpled-paper cells
Ashkenazi Jew AR glucocerebrosidase
Flashcard 7: Patau's syndrome
Answer: Trisomy 13
Key features: Microphthalmia, Microcephaly, Cleft lip/palate, Polydactyly, Holoprosencephaly, and Rocker-bottom feet.
Extra: First trimester pregnancy screen:
- Decreased β-hCG
- Decreased PAPP-A
- Ultrasound: Increased nuchal translucency
Note: Most cases result in death within the first year of life.
Flashcard 8: In metachromatic leukodystrophy, sulfatides accumulate in the lysosomes of _____
Answer: oligodendrocytes
Extra:
https://onlinemeded.org/spa/metabolism?ref=anki
Atlas:
Flashcard 9: What type of cast may be seen in end-stage renal disease and chronic renal failure?
_____
Answer: Waxy casts
Extra:
Watch Chronic Kidney Disease (CKD) [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-renal/videos/medical-pathophysiology-renal-congenital-and-chronic-kidney-disease-chronic-kidney-disease-ckd?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/nephrology/videos/pathology-diagnostics?index=6]
https://onlinemeded.org/spa/nephrology/acute-kidney-injury/acquire?ref=anki
Step Up to Medicine:
Other:
Goljan:
Flashcard 10: _____ is characterized histologically by acanthosis with parakeratosis
Answer: Psoriasis
Extra:
Watch associated Bootcamp video [https://app.bootcamp.com/med-school/dermatology/videos/inflammatory-diseases-of-the-skin?index=10]
https://onlinemeded.org/spa/musculoskeletal/inflammatory-dermatoses/acquire?ref=anki
Atlas:
Keywords: Skeletal muscle diseases flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards
