Systemic Pathology — Flashcards

Flashcard 281: Chédiak-Higashi syndrome is characterized by _____ circulating neutrophils

Answer: decreased

Flashcard 282: The diagnosis of Alzheimer's disease is confirmed by histology at _____ (when possible)

Answer: autopsy

Extra: Atlas:

Flashcard 283: The "spike" appearance in _____ is due to the basement membrane engulfing "domes" of subepithelial immune deposits

Answer: membranous glomerulopathy

Flashcard 284: Cystine kidney stones are characterized by urine crystals that are _____ in shape

Answer: hexagonal

Flashcard 285: Which endocrine tumor is characterized by granular cytoplasm and small nests of spindle-like chromaffin cells "Zellballen"? _____

Answer: Pheochromocytoma

Flashcard 286: Polycystic kidney disease may compress the renal parenchyma and cause irreversible damage leading to _____

Answer: chronic kidney disease

Flashcard 287: What type of nephritic syndrome is a patient with SLE most likely to get? _____

Answer: Diffuse proliferative glomerulonephritis

Extra: Atlas:

Flashcard 288: Osteopetrosis may occur due to mutations in _____, which leads to loss of the acidic environment necessary for bone resorption

Answer: carbonic anhydrase II

Extra: - normally, CA II produces carbonic acid (H2CO3) from CO2 and H2O, which dissociates to bicarbonate (HCO3) and a proton (H+)

Flashcard 289: The tissue-restricted self-antigens expressed in the thymus for negative selection are due to the action of _____

Answer: autoimmune regulator (AIRE)

Flashcard 290: PSGN may display _____ infiltrate in the mesangium and endothelium on light microscopy

Answer: leukocyte (lots of nuclei present)