Systemic Pathology — Flashcards

Flashcard 211: IL-_____ receptor deficiency is characterized by a decreased Th1 response

Answer: 12

Flashcard 212: _____ is the most common cause of dwarfism

Answer: Achondroplasia

Flashcard 213: Which autoimmune disease is characterized by sclerosis of skin and visceral organs? _____

Answer: Scleroderma (systemic sclerosis)

Flashcard 214: Mild osteopetrosis is a(n) autosomal dominant "marble bone disease" that presents in _____

Answer: adolescence or adulthood

Extra: Osteopetrosis ("marble bone disease") is caused by defective osteoclasts (e.g., due to Carbonic Anhydrase II deficiency or proton pump mutations), resulting in failure of bone resorption. The bone is thickened and dense but lacks normal structure, making it prone to fractures. - **Autosomal Dominant (AD)**: Mild/Adult form (Albers-Schönberg disease), often presents in adolescence or adulthood. - **Autosomal Recessive (AR)**: Severe/Infantile form, presents with bone marrow failure and cranial nerve palsies.

Flashcard 215: Calcium phosphate kidney stones are characterized by urine crystals in the shape of a(n) _____

Answer: wedge-shaped prism

Flashcard 216: Is polycystic kidney disease heritable? _____

Answer: Yes

Extra: Atlas:

Flashcard 217: Which two antibodies are associated with Hashimoto thyroiditis? _____ and anti-thyroid peroxidase (anti-microsomal)

Answer: Anti-thyroglobulin

Extra: Atlas: Compare with TSI for Graves

Flashcard 218: Hepatitis _____ infections are more likely to cause membranoproliferative glomerulonephritis (MPGN)

Answer: C

Flashcard 219: Aldosterone-secreting adenomas often display "_____", which are eosinophilic cytoplasmic inclusions

Answer: spironolactone bodies

Extra: * due to treatment with spironolactone

Flashcard 220: Rheumatoid arthritis is associated with _____, which are areas of fibrinoid necrosis with palisading histiocytes in the skin and visceral organs (e.g. lung)

Answer: rheumatoid nodules

Extra: Atlas: