Systemic Pathology — Flashcards

Flashcard 201: Type 1 diabetes mellitus is due to _____ (T-cell mediated) of pancreatic β cells; associated with anti-glutamic acid decarboxylase antibodies

Answer: autoimmune destruction

Extra: Type 1 DM is a Type IV hypersensitivity reaction (T-cell mediated). Autoantibodies (e.g., GAD-65, insulin autoantibodies) are markers of cell damage rather than the primary mediators of destruction.

Flashcard 202: Plasmodium spp. infect _____ cells

Answer: red blood

Flashcard 203: Neuropathology showing spongiform degeneration and vacuole formation in grey matter structures (e.g. caudate, putamen) without inflammation is suggestive of _____

Answer: Creutzfeldt-Jakob disease

Flashcard 204: Baker cyst forms in the setting of _____ disease

Answer: chronic degenerative or inflammatory joint

Flashcard 205: Uric acid kidney stones are characterized by urine crystals in the shape of a(n) _____ or rosettes

Answer: rhomboid

Flashcard 206: Diagnosis of Sjögren's syndrome is confirmed by presence of focal _____ on labial salivary gland biopsy

Answer: lymphocytic sialadenitis

Extra: Atlas:

Flashcard 207: In minimal change disease (lipoid nephrosis), _____ may be seen in proximal tubule cells of the nephron (light microscopy)

Answer: lipids

Extra: Atlas:

Flashcard 208: Changes in brain structure associated with CMV can result in mental retardation and _____

Answer: seizures

Flashcard 209: Imaging of the helminth Echinococcus granulosus reveals hydatid cysts with '_____' calcifications, most commonly in the _____

Answer: eggshell

Flashcard 210: IL-_____ receptor deficiency is characterized by a decreased Th1 response

Answer: 12