Systemic Pathology — Flashcards

Flashcard 141: When performing Immunohistochemistry; Thyroglobulin can be used to identify malignancies of the _____

Answer: Thyroid

Flashcard 142: Which blistering skin disorder is characterized by a "fish net" (reticular) pattern on immunofluorescence? _____

Answer: Pemphigus vulgaris

Extra: Due to the auto-IgG antibodies attacking desmosomes Oral Mucosa, Net-Like Pattern: Think of a "pimp" having people suck with their mouth, but first he has to put on his net (condom). Atlas:

Flashcard 143: In diabetes mellitus, high serum glucose leads to _____ of the GBM in the kidney

Answer: non-enzymatic glycosylation

Flashcard 144: Tabes Dorsalis is characterized by _____ joints due to loss of proprioception

Answer: charcot

Flashcard 145: Secondary amyloidosis is characterized by systemic deposition of _____, which is derived from serum amyloid-associated protein (SAA)

Answer: AA amyloid

Extra: * Amyloid AA - composed of fragments of serum amyloid A (SAA) protein, a major acute-phase reactant protein, produced predominantly by hepatocytes

Flashcard 146: Achondroplasia is associated with increased _____ age

Answer: paternal

Flashcard 147: Flow Cytometry Example: Cells in the left lower quadrant are CD3_____ and CD8_____

Answer: -

Flashcard 148: Hemochromatosis is associated with HLA-_____

Answer: A3

Extra: Atlas:

Flashcard 149: Granulomatosis with polyangiitis (Wegener) is a form of _____-vessel vasculitis

Answer: small

Extra: Atlas:

Flashcard 150: What RBC pathology is characterized by the following Hb electrophoresis findings: 90% HbS, 8% HbF, and 2% HbA2 (no HbA) _____

Answer: Sickle cell disease