Systemic Pathology — Flashcards

Flashcard 131: Type 1 DM is caused by autoimmune destruction of β cells by _____ cells and autoantibodies produced by B cells

Answer: CD8+ T

Extra: * CD8+ killer T-cells attack pancreatic beta cells (occurs as a result of T cells losing "self-tolerance")

Flashcard 132: Which blood transfusion reaction can be caused by host antibodies against donor HLA antigens and donor WBCs? _____

Answer: Febrile nonhemolytic transfusion reaction

Extra: FA2020:

Flashcard 133: Mucormycosis will penetrate the _____ of the skull, entering the _____

Answer: cribriform plate

Flashcard 134: Testicular tumors may arise from either _____ or _____

Answer: germ cells

Flashcard 135: Downward transtentorial (central) herniation may result in rupture of the _____ branches of the basilar artery, which cause Duret hemorrhages

Answer: paramedian

Extra: Atlas:

Flashcard 136: What finding emerges on blood smear following splenectomy in a patient with hereditary spherocytosis? _____

Answer: Howell-Jolly bodies

Extra: Atlas: Other:

Flashcard 137: _____ of tertiary syphilis can occur on the skin, bones or internal organs

Answer: Gummas

Flashcard 138: Infantile malignant osteopetrosis is a(n) _____ bone disorder that is often fatal in infancy due to severe leukopenia

Answer: autosomal recessive

Extra: * Over 50% of cases are due to mutations in the TCIRG1 gene

Flashcard 139: _____ is characterized by degeneration of the macula

Answer: Age-related macular degeneration

Extra: Atlas:

Flashcard 140: Type _____ collagen is targeted by autoantibodies in Goodpasture syndrome

Answer: IV