Systemic Pathology — Flashcards

Flashcard 151: Flow Cytometry Example: Cells in the left lower quadrant are CD3_____ and CD8_____

Answer: -

Flashcard 152: Squamous cell carcinoma of the lung is _____ located

Answer: centrally

Flashcard 153: Paget disease of bone is characterized by _____ serum alkaline phosphatase

Answer: elevated

Extra: Atlas:

Flashcard 154: Hemophagocytic lymphohistiocytosis is characterized by very increased levels of _____

Answer: ferritin

Flashcard 155: The number of neurofibrillary tangles in Alzheimer's correlates with degree of _____

Answer: dementia

Extra: Neurofibrillary tangles (NFTs) are **intracellular** aggregates of hyperphosphorylated **tau protein**. The density and distribution of tangles correlate strongly with the degree of dementia. In contrast, **senile plaques** are **extracellular** deposits of **amyloid-β** (Aβ).

Flashcard 156: What is the first stage of Paget disease of bone (osteitis deformans)? _____

Answer: Osteoclastic (lytic)

Extra: Atlas:

Flashcard 157: The longer life of reticulocytes in anemia can be corrected for by _____ (reticulocyte production index)

Answer: corrected reticulocyte count / maturation time

Flashcard 158: Cutaneous involvement in _____ commonly manifests as a verrucous lesion with irregular borders that may mimic squamous cell carcinoma

Answer: blastomycosis

Flashcard 159: Is the metabisulfite screen positive in sickle cell disease or trait? _____

Answer: Both :)

Extra: Other:

Flashcard 160: In adults, woven bone is seen _____ and in Paget disease

Answer: after fractures